Study on motor function imaging developed for quantitative evaluation of rehabilitation effects

定量评估康复效果的运动功能成像研究

• 批准号: 17300148
• 负责人: MIYAKAWA Michio
• 金额: $ 9.96万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17300148/
• 关键词: Exercise; Fatigue of muscle; Image-based measurement; Microwave imaging; Optical diffusion imaging; Functional imaging; Oxidization level; Ox hemoglobin; 筋電図; 酸素飽和度; 動脈血酸素分圧; 機能イメージング; マイクロ波CT; 機能の可視化; リハビリテーション効果; 筋活動; 疲労; 生理的変化

The objective of this study is to demonstrate the possibility of motor function imaging by use of the microwave imaging modality called CP-MCT that was developed by our groups. The imaging modality basically visualizes the cross-sectional distribution of the attenuation and/or phase shift of microwaves in the biological tissues. Since the reconstructed image of CP-MCT reflects the physical- or chemical-change in the tissues, it is expected that rehabilitation effects are visualized through those physical- or chemical changes mainly in the muscles In order to visualize the effects of exercise, gripping loads were applied to the forearm muscles for 5 minutes. To observe slight changes in the physical- or chemical parameters of the muscle, images obtained before and after having exercises were compared by means of image subtraction between those two images. The physiological condition of muscles under gripping load was monitored by means of electromyography and the optical diffusion imagi … More ng of the corresponding forearm portions was also attempted to gain access information of oxidization in the muscles.The image subtraction between two CP-MCT images revealed the bone regions clearly, because the gray level did not change in the bone regions. Conversely, the gray level in the other regions showed an uneven distribution probably due to the difference in the muscle activities. In fact, fatigue of muscles was confirmed by the electromyography in some experiments. The optical diffusion tomography showed oxidization processes in various muscles and vessels. Some of those images showed a reasonable distribution of oxi- and deoxi-hemoglobin. Although the strong relationships between the optical diffusion image and subtracted CP-MCT image were not found in this study, the areas of gray level change showed close resemblance. Therefore, it will be concluded that new modality using chirp pulse microwaves will be used for evaluating the rehabilitation effects by improving the measurement techniques. Less

这项研究的目的是通过使用由我们组开发的称为CP-MCT的微波成像模态来证明运动功能成像的可能性。成像方式基本上可视化生物组织中微波的衰减和/或相移的横截面分布。由于CP-MCT的重建图像反映了组织中的物理或化学变化，因此预计通过这些物理或化学变化可视化康复效应，主要是在肌肉中以可视化运动的影响，因此将抓地负荷施加到前臂肌肉中5分钟。为了观察肌肉的物理或化学参数的略有变化，通过这两个图像之间的图像减法比较了在进行练习之前和之后获得的图像。通过肌电图监测了肌肉肌肉的物理状况，并且还试图尝试获得相应的正向部分的光学扩散想象，以获取肌肉中氧化的访问信息。两个CP-MCT图像之间的图像减法揭示了骨骼区域清楚地揭示了骨骼区域，因为灰度在骨骼区域没有变化。相反，其他区域的灰度表明分布不均可能是由于肌肉活动的差异。实际上，肌电图在某些实验中证实了肌肉的疲劳。光学扩散断层扫描显示各种肌肉和视频中的氧化过程。其中一些图像显示了氧氧和脱氧 - 血红蛋白的合理分布。尽管在这项研究中找不到光学扩散图像和减去CP-MCT图像之间的牢固关系，但灰度变化的区域显示出非常相似的区域。因此，将得出结论，使用Chirp脉冲微波的新方式将用于通过改进测量技术来评估康复效应。较少的

项目成果

A linear model chirp-pulse microwave computerized tomography : Applicability conditions

线性模型线性调频脉冲微波计算机断层扫描：适用条件

• 发表时间: 2006
• 期刊: Inverse Problems 22
• 作者: A.M.Massone;M.Miyakawa;M.Piana;F.Conte;M.Bertero
• 通讯作者: M.Bertero

CP-MCTによる四肢マイクロ波イメージング-数値解析及び実測による検討-

使用 CP-MCT 的肢体微波成像 - 基于数值分析和实际测量的研究 -

• 发表时间: 2007
• 作者: 横尾高史

The development of leukocyte counter using fluorescence imaging analysis

荧光成像分析白细胞计数器的研制

• 发表时间: 2005
• 期刊: Optical and Quantum Electronics 17・8
• 作者: 谷川;山田;宮川;ほか4名;M. Watanabe;M. Miyakawa;N. Ishii;石井 望;H. Zhao;T. Hirono
• 通讯作者: T. Hirono

四肢計測用チャープパルスマイクロ波CT -数値解析と実験による検討-

用于肢体测量的啁啾脉冲微波CT-数值分析与实验研究-

• 发表时间: 2007
• 期刊: 電子情報通信学会技術研究報告, ICICE-MBE2007-68 107-351
• 作者: 西野美晴;鈴木隆文;M. Miyakawa;Y. Miyazaki;A. Marjono;H. Zhao;A. Marjono;A. Marjono;T. Hirono;M. Ueno;N.Shibahara;岩田直之;横尾高史
• 通讯作者: 横尾高史

In vivo measurement of premature neonate head using diffuse optical tomography

使用漫射光学断层扫描对早产儿头部进行体内测量

• 发表时间: 2007
• 期刊: Abstract Book APBP 2007, 3rd Asian and Pacific Rim Symposium on Biophotonics 1
• 作者: 西野美晴;鈴木隆文;M. Miyakawa;Y. Miyazaki;A. Marjono;H. Zhao;A. Marjono;A. Marjono;T. Hirono;M. Ueno
• 通讯作者: M. Ueno