Study on motor function imaging developed for quantitative evaluation of rehabilitation effects

定量评估康复效果的运动功能成像研究

• 批准号: 17300148
• 负责人: MIYAKAWA Michio
• 金额: $ 9.96万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17300148/
• 关键词: Exercise; Fatigue of muscle; Image-based measurement; Microwave imaging; Optical diffusion imaging; Functional imaging; Oxidization level; Ox hemoglobin; 筋電図; 酸素飽和度; 動脈血酸素分圧; 機能イメージング; マイクロ波CT; 機能の可視化; リハビリテーション効果; 筋活動; 疲労; 生理的変化

The objective of this study is to demonstrate the possibility of motor function imaging by use of the microwave imaging modality called CP-MCT that was developed by our groups. The imaging modality basically visualizes the cross-sectional distribution of the attenuation and/or phase shift of microwaves in the biological tissues. Since the reconstructed image of CP-MCT reflects the physical- or chemical-change in the tissues, it is expected that rehabilitation effects are visualized through those physical- or chemical changes mainly in the muscles In order to visualize the effects of exercise, gripping loads were applied to the forearm muscles for 5 minutes. To observe slight changes in the physical- or chemical parameters of the muscle, images obtained before and after having exercises were compared by means of image subtraction between those two images. The physiological condition of muscles under gripping load was monitored by means of electromyography and the optical diffusion imagi … More ng of the corresponding forearm portions was also attempted to gain access information of oxidization in the muscles.The image subtraction between two CP-MCT images revealed the bone regions clearly, because the gray level did not change in the bone regions. Conversely, the gray level in the other regions showed an uneven distribution probably due to the difference in the muscle activities. In fact, fatigue of muscles was confirmed by the electromyography in some experiments. The optical diffusion tomography showed oxidization processes in various muscles and vessels. Some of those images showed a reasonable distribution of oxi- and deoxi-hemoglobin. Although the strong relationships between the optical diffusion image and subtracted CP-MCT image were not found in this study, the areas of gray level change showed close resemblance. Therefore, it will be concluded that new modality using chirp pulse microwaves will be used for evaluating the rehabilitation effects by improving the measurement techniques. Less

本研究的目的是证明运动功能成像的可能性，通过使用微波成像模式称为CP-MCT，是由我们的小组开发的。成像模态基本上使生物组织中的微波的衰减和/或相移的横截面分布可视化。由于CP-MCT的重建图像反映了组织中的物理或化学变化，因此预期通过主要在肌肉中的那些物理或化学变化来可视化康复效果。为了可视化锻炼的效果，将抓握负荷施加到前臂肌肉5分钟。为了观察肌肉的物理或化学参数的轻微变化，通过在这两个图像之间的图像减影的方式来比较在锻炼之前和之后获得的图像。采用肌电图和光学弥散成像技术监测握力负荷下肌肉的生理状态， ...更多信息 两幅CP-MCT图像之间的图像相减，由于骨骼区域的灰度值没有变化，因此可以清晰地显示骨骼区域。相反，其他区域的灰度值显示出不均匀的分布，可能是由于肌肉活动的差异。事实上，肌肉疲劳在一些实验中被肌电图证实。光学扩散断层扫描显示各种肌肉和血管中的氧化过程。其中一些图像显示了氧和脱氧血红蛋白的合理分布。虽然在本研究中未发现光学扩散图像与减影CP-MCT图像之间的强相关性，但灰度变化区域显示出密切的相似性。因此，可以得出结论，使用啁啾脉冲微波的新模式将用于通过改进测量技术来评估康复效果。少

项目成果

A linear model chirp-pulse microwave computerized tomography : Applicability conditions

线性模型线性调频脉冲微波计算机断层扫描：适用条件

• 发表时间: 2006
• 期刊: Inverse Problems 22
• 作者: A.M.Massone;M.Miyakawa;M.Piana;F.Conte;M.Bertero
• 通讯作者: M.Bertero

The development of leukocyte counter using fluorescence imaging analysis

荧光成像分析白细胞计数器的研制

• 发表时间: 2005
• 期刊: Optical and Quantum Electronics 17・8
• 作者: 谷川;山田;宮川;ほか4名;M. Watanabe;M. Miyakawa;N. Ishii;石井 望;H. Zhao;T. Hirono
• 通讯作者: T. Hirono

CP-MCTによる四肢マイクロ波イメージング-数値解析及び実測による検討-

使用 CP-MCT 的肢体微波成像 - 基于数值分析和实际测量的研究 -

• 发表时间: 2007
• 作者: 横尾高史

Fan Beam-Type CP-MCT with Microstrip Dipole Array Receiving Antenna

扇束式CP-MCT微带偶极子阵列接收天线

• 发表时间: 2006
• 期刊: Proceedings of 36th European Microwave Conference (CD-ROM)
• 作者: N. Shibahara;S. Okawa;Y. Yamada;A. M. Massone;M. Watanabe;M. Miyakawa
• 通讯作者: M. Miyakawa

In vivo measurement of premature neonate head using diffuse optical tomography

使用漫射光学断层扫描对早产儿头部进行体内测量

• 发表时间: 2007
• 期刊: Abstract Book APBP 2007, 3rd Asian and Pacific Rim Symposium on Biophotonics 1
• 作者: 西野美晴;鈴木隆文;M. Miyakawa;Y. Miyazaki;A. Marjono;H. Zhao;A. Marjono;A. Marjono;T. Hirono;M. Ueno
• 通讯作者: M. Ueno