Study on motor function imaging developed for quantitative evaluation of rehabilitation effects

定量评估康复效果的运动功能成像研究

• 批准号: 17300148
• 负责人: MIYAKAWA Michio
• 金额: $ 9.96万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17300148/
• 关键词: Exercise; Fatigue of muscle; Image-based measurement; Microwave imaging; Optical diffusion imaging; Functional imaging; Oxidization level; Ox hemoglobin; 筋電図; 酸素飽和度; 動脈血酸素分圧; 機能イメージング; マイクロ波CT; 機能の可視化; リハビリテーション効果; 筋活動; 疲労; 生理的変化

The objective of this study is to demonstrate the possibility of motor function imaging by use of the microwave imaging modality called CP-MCT that was developed by our groups. The imaging modality basically visualizes the cross-sectional distribution of the attenuation and/or phase shift of microwaves in the biological tissues. Since the reconstructed image of CP-MCT reflects the physical- or chemical-change in the tissues, it is expected that rehabilitation effects are visualized through those physical- or chemical changes mainly in the muscles In order to visualize the effects of exercise, gripping loads were applied to the forearm muscles for 5 minutes. To observe slight changes in the physical- or chemical parameters of the muscle, images obtained before and after having exercises were compared by means of image subtraction between those two images. The physiological condition of muscles under gripping load was monitored by means of electromyography and the optical diffusion imagi … More ng of the corresponding forearm portions was also attempted to gain access information of oxidization in the muscles.The image subtraction between two CP-MCT images revealed the bone regions clearly, because the gray level did not change in the bone regions. Conversely, the gray level in the other regions showed an uneven distribution probably due to the difference in the muscle activities. In fact, fatigue of muscles was confirmed by the electromyography in some experiments. The optical diffusion tomography showed oxidization processes in various muscles and vessels. Some of those images showed a reasonable distribution of oxi- and deoxi-hemoglobin. Although the strong relationships between the optical diffusion image and subtracted CP-MCT image were not found in this study, the areas of gray level change showed close resemblance. Therefore, it will be concluded that new modality using chirp pulse microwaves will be used for evaluating the rehabilitation effects by improving the measurement techniques. Less

这项研究的目的是证明使用我们小组开发的名为CP-MCT的微波成像模式进行运动功能成像的可能性。成像模式基本上显示了生物组织中微波衰减和/或相移的横截面分布。由于CP-MCT的重建图像反映了组织中的物理或化学变化，因此预期康复效果主要通过肌肉中的物理或化学变化来可视化。为了直观显示运动的效果，对前臂肌肉施加握力5min。为了观察肌肉的物理或化学参数的轻微变化，将运动前后的图像通过图像减去的方法进行比较。用肌电图仪和光学弥散成像…监测握力负荷下肌肉的生理状态两幅CP-MCT图像之间的减影可以清晰地显示骨骼区域，因为骨骼区域的灰度级没有变化。相反，其他区域的灰度级分布不均匀，可能是由于肌肉活动的差异。事实上，在一些实验中，肌电图证实了肌肉的疲劳。光扩散断层扫描显示不同肌肉和血管的氧化过程。其中一些图像显示了氧合和脱氧血红蛋白的合理分布。虽然在本研究中，光学弥散图像与减影的CP-MCT图像之间没有很强的相关性，但灰度变化的区域显示出非常相似的地方。因此，通过改进测量技术，可以得出结论，利用啁啾脉冲微波的新模式将被用于评估康复效果。较少

项目成果

A linear model chirp-pulse microwave computerized tomography : Applicability conditions

线性模型线性调频脉冲微波计算机断层扫描：适用条件

• 发表时间: 2006
• 期刊: Inverse Problems 22
• 作者: A.M.Massone;M.Miyakawa;M.Piana;F.Conte;M.Bertero
• 通讯作者: M.Bertero

The development of leukocyte counter using fluorescence imaging analysis

荧光成像分析白细胞计数器的研制

• 发表时间: 2005
• 期刊: Optical and Quantum Electronics 17・8
• 作者: 谷川;山田;宮川;ほか4名;M. Watanabe;M. Miyakawa;N. Ishii;石井 望;H. Zhao;T. Hirono
• 通讯作者: T. Hirono

CP-MCTによる四肢マイクロ波イメージング-数値解析及び実測による検討-

使用 CP-MCT 的肢体微波成像 - 基于数值分析和实际测量的研究 -

• 发表时间: 2007
• 作者: 横尾高史

Fan Beam-Type CP-MCT with Microstrip Dipole Array Receiving Antenna

扇束式CP-MCT微带偶极子阵列接收天线

• 发表时间: 2006
• 期刊: Proceedings of 36th European Microwave Conference (CD-ROM)
• 作者: N. Shibahara;S. Okawa;Y. Yamada;A. M. Massone;M. Watanabe;M. Miyakawa
• 通讯作者: M. Miyakawa

In vivo measurement of premature neonate head using diffuse optical tomography

使用漫射光学断层扫描对早产儿头部进行体内测量

• 发表时间: 2007
• 期刊: Abstract Book APBP 2007, 3rd Asian and Pacific Rim Symposium on Biophotonics 1
• 作者: 西野美晴;鈴木隆文;M. Miyakawa;Y. Miyazaki;A. Marjono;H. Zhao;A. Marjono;A. Marjono;T. Hirono;M. Ueno
• 通讯作者: M. Ueno