Phenotypic differences in behaviour, brain function and structure of genetically dissimilar forms of intellectual disability.

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How is the brain of someone with intellectual disability different from that of a normal person? Are behavioural phenotypes such as intellectual disability more related to similarities in brain structure and function than to the genotypic anomaly? This project will use neuroscience techniques of psychophysics, electrophysiology and fMRI to probe these questions. The benefit of this project is that cortical flattening fMRI techniques together with new and efficient stimulus paradigms will result in a functional landmark mapping tool capable of application to many other brain genotype-phenotype questions. Also, the functional brain basis of intellectual disability will be further revealed.