Phenotypic differences in behaviour, brain function and structure of genetically dissimilar forms of intellectual disability.

遗传上不同形式的智力障碍在行为、大脑功能和结构方面的表型差异。

• 批准号: DP0345767
• 负责人: Adj/Prof David Crewther
• 金额: $ 17.1万
• 依托单位: Swinburne University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2007-10-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0345767
• 关键词: Phenotypic; differences; behaviour; brain; function

How is the brain of someone with intellectual disability different from that of a normal person? Are behavioural phenotypes such as intellectual disability more related to similarities in brain structure and function than to the genotypic anomaly? This project will use neuroscience techniques of psychophysics, electrophysiology and fMRI to probe these questions. The benefit of this project is that cortical flattening fMRI techniques together with new and efficient stimulus paradigms will result in a functional landmark mapping tool capable of application to many other brain genotype-phenotype questions. Also, the functional brain basis of intellectual disability will be further revealed.

智力残疾者的大脑与正常人的大脑有什么不同？行为表型（如智力残疾）是否与大脑结构和功能的相似性比与基因型异常更相关？本计画将利用神经科学的心理物理学、电生理学及功能性磁振造影技术来探讨这些问题。这个项目的好处是，皮质扁平化功能磁共振成像技术与新的和有效的刺激范例将导致一个功能性地标映射工具，能够应用到许多其他大脑基因型表型的问题。并进一步揭示智力残疾的脑功能基础。