权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Development of Measuring System for In Vitro Hemodynamics and Evaluation of Fluid Forces Acting on Blood Vessel Walls

体外血流动力学测量系统的开发和作用于血管壁的流体力的评估

基本信息

批准号：
17360077
负责人：
NISHINO Koichi
金额：
$ 6.72万
依托单位：
Yokohama National University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

The present study has two main objectives. The first one is to develop a measuring system for fluid forces (i.e., pressure and shear stresses) acting on blood vessel walls and thus for pulsating characteristics of those fluid forces. The second one is to evaluate, by using the system developed, such fluid forces through in vitro experiment using aneurysm models made from MRI data taken from real patients. An additional objective is to conduct 3-D fluid flow computations using the MRI data in order to obtain information of fluid dynamic quantities unavailable from experiment The outcomes are as follows:(1) Stereo PIV measurements based on the index-matching technique are carried out by using silicone-rubber models of cerebral aneurysm made from MRI data taken from real patients. Distributions of three-component mean velocities in multiple cross-sections in two aneurysm models, a ruptured model and an unruptured model, are measured at three steady velocity conditions.(2) A method for evaluating, from three-component velocity distributions measured, the wall shear stresses acting on the aneurysm walls. Particular attention is paid to the interpolation scheme for velocities near the wall.(3) The method is applied to the data taken in the stereo PIV measurements. The wall shear stresses are evaluated and the effect of the uncertainties in the wall position is examined.(4) A method for 3-D computations for fluid flows in cerebral aneurysms using exported data from MRI models is studied. A commercially available CFD code is utilized and the inlet and outlet conditions appropriate from hemodynamics in cerebral aneurysm are determined.(5) The CFD method is used to investigate both steady and pulsatile fluid flows in three different aneurysm models, a ruptured model, an unruptured model and a to-be-ruptured model. Velocity distributions, wall pressure distributions and wall shear stress distributions are clarified from the computed results.

本研究报告有两个主要目标。第一个是开发一种用于流体力的测量系统（即，压力和剪切应力）作用在血管壁上，并因此用于这些流体力的脉动特性。第二个是通过使用所开发的系统，通过使用从真实的患者的MRI数据制成的动脉瘤模型的体外实验来评估这样的流体力。另外一个目的是利用MRI数据进行三维流体流动计算，以获得实验中无法获得的流体动力学量信息。结果如下：（1）利用取自真实的患者的MRI数据制成的硅橡胶脑动脉瘤模型，进行了基于指数匹配技术的立体PIV测量。在三种稳态速度条件下，测量了两个动脉瘤模型（破裂模型和未破裂模型）的多个横截面上的三分量平均速度分布。(2)一种从测量的三分量速度分布评估作用于动脉瘤壁上的壁面剪应力的方法。特别注意的是插值方案的速度近壁。(3)该方法适用于在立体PIV测量的数据。壁面剪应力的评价和壁面位置的不确定性的影响进行了检查。(4)研究了一种利用MRI模型输出数据进行脑动脉瘤内流体流动三维计算的方法。利用商业上可获得的CFD代码，并从脑动脉瘤的血流动力学确定适当的入口和出口条件。(5)采用CFD方法研究了三种不同动脉瘤模型（破裂模型、未破裂模型和待破裂模型）中的稳态和脉动流体流动。计算结果揭示了流场的速度分布、壁面压力分布和壁面剪应力分布。