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Optical Tomography of Biological Tissue Based on Optically Assisted Ultrasonic Velocity-change Imaging

基于光学辅助超声变速成像的生物组织光学断层扫描

基本信息

批准号：
17360193
负责人：
HORINAKA H.
金额：
$ 7.68万
依托单位：
Osaka Prefecture University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17360193/
关键词：
optical tomography ultrasonic velocity diagnostic imaging apparatus ultrasonic transducer echo pulse gold nano-particle drug delivery system gold nano-rod 超音波アレイトランスデューサ超音波アレイトランスデューサー

项目摘要

We have already shown that the optical absorption distribution of the tissue mimic sample was able to be obtained by detection of ultrasonic echo pulse shift induced by light illumination. However, the experimental equipment using the single ultrasonic transducer is inadequate for the clinical application because echo data acquisition takes time to scan the transducer mechanically. We remodeled the commercial-type product of diagnostic ultrasonic equipment and obtained quickly the image of optical absorption distribution constructed by detection of ultrasonic velocity change using the ultrasonic array transducer.The array transducer was mounted above the phantom. The optical fibers attached to the high-power diode laser were arranged around the array transducer to illuminate the phantom. The echo pulses and their waveform data through the array transducer of the diagnostic ultrasound equipment were stored in a personal computer before light illumination. After light illumination, the echo pulses and their waveform data were also stored. The waveforms of echo pulses were interpolated to increase the sampling points and were divided into small areas with the width of transmitted pulse. The cross-correlation between the corresponding area of the waveform data stored before and after light illumination was calculated to measure the echo pulse shift induced by light illumination.Chicken meat phantoms in cluding the dyed agar or Au nano-rods were prepared as phantoms.The ultrasonic velocity change image constructed from the echo pulse shift gradually showed the absorption region of the phantom depending illuminating time of the light. On the other hand, the B-mode image did not display the optical absorption area in the phantom at all and did not change with time.Experimental results showed that our method had the possibility of application to early detection of malignant tumors and as a practical monitor of Au nano-rods for the drug delivery system.

我们已经表明，组织模拟样品的光吸收分布能够通过检测由光照射引起的超声回波脉冲偏移来获得。然而，使用单个超声换能器的实验设备不足以用于临床应用，因为回波数据采集需要时间来机械地扫描换能器。我们对商用型超声诊断设备进行了改造，利用超声阵列换能器检测超声速度变化，快速获得了光学吸收分布图像，阵列换能器安装在体模上方。将连接到高功率二极管激光器的光纤布置在阵列换能器周围以照亮体模。通过超声诊断仪的阵列换能器的回波脉冲及其波形数据在光照前存储在个人计算机中。在光照后，回波脉冲及其波形数据也被存储。对回波脉冲波形进行插值，增加采样点数，并根据发射脉冲宽度将回波脉冲波形划分为小区域。通过计算光照射前后波形数据对应面积的互相关，测量光照射引起的回波脉冲位移，制备含有染色琼脂或Au纳米棒的鸡肉模型，由回波脉冲位移构建的超声速度变化图像逐渐显示模型的吸收区域随光照射时间的变化。实验结果表明，该方法可以应用于恶性肿瘤的早期检测，并可作为Au纳米棒药物释放系统的实用监测器。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

光トモグラフィ装置用プローブ

光学断层扫描设备探头

DOI：
发表时间：
2006
期刊：
影响因子：
0
作者：
通讯作者：

Real Time Optical Tomography of Biological Tissue by Detection of Ultrasonic Velocity Change Due to Light Illumination

通过检测光照射引起的超声波速度变化对生物组织进行实时光学断层扫描

DOI：
发表时间：
2006
期刊：
Proceedings of 2006 IEEE International Ultrasonic Symposium (Vancouver, Canada, October 3-6, 2006)
影响因子：
0
作者：
金原和哉;他;Yasunori Saito;Fumihiko Nishinaka 他4名;Hiromichi Horinaka 他5名
通讯作者：
Hiromichi Horinaka 他5名

光アシスト超音波速度変化イメージング装置および光アシスト超音波速度変化画像表示方法

光辅助超声速度变化成像装置及光辅助超声速度变化图像显示方法