Mechanism of immuno-heat therapy for breast cancer using herceptin conjugated magnetoliposome

赫赛汀偶联磁脂质体免疫热疗治疗乳腺癌的机制

• 批准号: 17390348
• 负责人: IMAI Tsuneo
• 金额: $ 10.62万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390348/
• 关键词: 乳癌; 温熱免疫療法; ハーセプチン; マグネタイト; リポソーム

ハーセプチンが表面に結合したマグネタイトを含んだリポソーム(HML)を開発した。ヌードマウス移植ヒト乳癌皮下腫瘍のモデルで、腫瘍へのHML局注により48時間までHMLは局所に残留し、他臓器移行はきわめて少ないことが示された。局注直後、24時間後に各々30分の交番磁場照射で、腫瘍のみを特異的に加温することができ、その結果腫瘍のほぼ完全な消退をもたらすことが確認された。以上からHMLは乳癌組織特異的温熱療法の発熱素材として用いうることが示され、再発乳癌において第I相臨床試験を計画することができた。

You need to make sure that you need to make sure that you have a real-time communication system (HML) on the surface. The breast cancer was implanted subcutaneously, and the HML was registered as residual in HML within 48 hours, and the other device was transferred to the breast cancer subcutaneously. Immediately after the local injection, 30 minutes after the local injection, 30 minutes after the local injection, the temperature of the magnetic field irradiation and the heating temperature of the special equipment were heated. The results showed that the temperature was completely eliminated and the temperature was confirmed. The warm-up method of the above HML breast cancer tissue is used to show the temperature of the breast cancer tissue, and then the first phase of the breast cancer is designed.

项目成果

Clinical experiment of mutant herpes simplex virus HF10 therapy for cancer.

突变型单纯疱疹病毒HF10治疗癌症的临床实验。

• 发表时间: 2007
• 期刊: Current Cancer Drag Targets 7-2
• 作者: Nakao A;Takeda S;Shimoyama S;Kasuya H;et al.
• 通讯作者: et al.

Anti-cancer effect of hyperthermia on breast cancer by magnetite 3 nanoparticle-loaded anti-HER2 immunoliposomes

磁石3纳米粒子负载抗HER2免疫脂质体热疗对乳腺癌的抗癌作用

• 发表时间: 2009
• 期刊: Breast Cancer Res Treat 113(3)
• 作者: Kikumori T;Kobayashi T;Sawaki M;Imai T.
• 通讯作者: Imai T.

Nodular Fasciitis of the Breast

乳房结节性筋膜炎

• 发表时间: 2007
• 期刊: Breast Cancer 14
• 作者: Hayashi H;Imai T;et. al.
• 通讯作者: et. al.

Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles : a novel concept of "heat-controlled necrosi " with heat shock protein expression

基于使用磁铁矿纳米粒子的细胞内热疗的癌症免疫治疗：具有热休克蛋白表达的“热控坏死”的新概念

• 发表时间: 2006
• 期刊: Cancer Immunology, Immunotherapy 55(3)
• 作者: Ito A;Honda H;Kobayashi T
• 通讯作者: Kobayashi T

Up-regulation of the gene encoding protein kinase A type I alpha regulatory subunit in nodular hyperplasia of parathyroid glands in patients with chronic renal failure.

慢性肾功能衰竭患者甲状旁腺结节性增生中编码蛋白激酶 A I 型 α 调节亚基的基因上调。

• 发表时间: 2006
• 期刊: The Journal of clinical endocrinology and metabolism Feb;91(2):5
• 作者: Matustani;T.;et. al.;Yatsuka Hibi;Yratsuka Hibi;日比 八束
• 通讯作者: 日比 八束