Development of hyperthermia using magnetic cationic liposome for refractory breast cancer and thyroid cancer

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A phase I study of hyperthermia using magnetic cationic liposome (MCL) and alternate magnetic field was conducted. Patients with refractory breast cancer, thyroid cancer, soft tissue sarcoma, and tongue cancer were enrolled. MCL (5mg/body) was locally injected to the recurrence site and alternate magnetic field was irradiated for 30 minutes to keep the temperature of the skin at 43 degree Celsius in the first 3 patients. MCL (50mg/body) was given and hyperthermia was conducted in the same manner in the next 3 patients. No adverse event was observed in all patients. The pathological examination 2 weeks after hyperthermia showed various local effects such as tumor necrosis, but there was no systemic benefit.