Abnormality of ubiquitin ligase controlling a TGF -βsignal and a study about the mechanism of the carcinoma

控制TGF-β信号的泛素连接酶异常及癌发生机制的研究

• 批准号: 17390354
• 负责人: TAKENOSHITA Seiichi
• 金额: $ 10.44万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390354/
• 关键词: TGF-β; ubigitin ligase; VEGF; Smurf1; Smurf2; ユビキチン; 癌; 転写活性

TGF - β is known as a tumor suppressor factor because of a cuticle cell does the proliferation control On the other hand, a cumulative action and the vascularization promotion action of the matrix out of cell, restraint for the immunity, charge cell line have various physiology activity, and that I work important for control of an increase / the differentiation of the cell is clarified. And it develops in the cancer of much Homo sapiens excessively and promotes a vascularization, and it is suggested as the factor which promotes permeation and the fibrosis of the cancer cell by letting you aggravate the destruction of the basement membrane, cell outside matrix accumulation, control and migration ability of the cell adhesion.Expression control of ubiquitin ligase dismantling Smad which is a receptor and a signal transmission molecule is suggested, but, about control adjustment of this TGF-β, the mechanism is not clarified.In this study, it is thought that it is it to a new index of the p … More roteome analysis in the future cancer research by analyzing the TGF-β signal abnormality in various cancer cells.In various cancer organizations, many reports are accomplished about expression analysis of the TGF-6 receptor and Smad gene group participating in a TGF-β signal till now. We paid our attention to Smurf1 and Smurf1 which were the HECT type E3 ligase which made Smad ubiquitin this time in TGF-β signal courses and examined correlation with the background factor of the clinical pathology by searching the expression in the cancer. Smurf2 to resolve HECT type E3 ubiquitin ligase Smurfl and active form TGF-β peculiar model Smad2 participating in the resolution of BM? peculiar model Smadl/5 into shifts in a nucleus and is connected with Smad7. The complex of both shifts to the nucleus outside for CRM1 dependence and has already understood that I am connected with a TGF-βI type acceptor and restrain signal transmission. I make a plan to be equal to or less than it based on the analysis result that was provided so far how expression in the cancer organization contributes to cancer biologically and study an experiment without it being still searched about the expression in the cancer organization in these Smurfl and Smurf2 enough and report it because I was able to get a constant analysis result. Less

TGF - β被称为肿瘤抑制因子，因为角质层细胞进行增殖控制。另一方面，细胞外基质的累积作用和血管化促进作用，对免疫的抑制，充电细胞系具有各种生理活性，并且阐明了我对控制细胞的增加/分化的重要作用。它在许多智人的癌症中过度发展并促进血管形成，它被认为是通过加重基底膜的破坏，细胞在基质外积累，细胞粘附的控制和迁移能力。作为受体和信号传递分子的泛素连接酶拆除Smad的表达控制，TGF-β的调控机制尚不清楚，本研究认为，TGF-β的调控机制可能是一个新的指标。 ...更多信息 迄今为止，在各种癌组织中，关于TGF-6受体和参与TGF-β信号的Smad基因组的表达分析已经完成了许多报道。本研究关注Smurf 1和Smurf 1在TGF-β信号通路中的表达，并通过寻找Smurf 1在肿瘤中的表达，研究其与临床病理背景因素的相关性。Smurf 2参与HECT型E3泛素连接酶Smurf 1和TGF-β特异性表达模式Smad 2参与BM的分解？一个特殊的模型Smad 1/5在一个核中的移动，并与Smad 7。两者的复合物转移到细胞核外的CRM 1依赖性，并已了解我与TGF-βI型受体连接并抑制信号传递。我基于到目前为止提供的分析结果制定了等于或小于它的计划，该分析结果表明癌症组织中的表达如何在生物学上有助于癌症，并且研究了一个实验，而不需要在这些Smurf 1和Smurf 2中仍然充分搜索癌症组织中的表达并报告它，因为我能够得到恒定的分析结果。少

项目成果

Circadian rhythm of apoprotein H (beta2-glycoprotein-1) in human plasma

人血浆中脱辅基蛋白 H（β2-糖蛋白-1）的昼夜节律

• 发表时间: 2007
• 期刊: Biochemical and Biophysical Research Communications 360(2)
• 作者: Higashimoto;M
• 通讯作者: M

Peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based detection test for gefitinib-refractory T790M epidermal growth factor receptor mutation

• DOI: 10.1111/j.1349-7006.2007.00706.x
• 发表时间: 2008-03-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Miyazawa, Hitoshi;Tanaka, Tomoaki;Hagiwara, Koichi
• 通讯作者: Hagiwara, Koichi

Primary adenocarcinoma of the minor duodenal papilla.

原发性十二指肠小乳头腺癌。

• 发表时间: 2008
• 期刊: Yonsei Medical Journal 49(2)
• 作者: Hiroshi Murata;Takahito Yagi;Tetsuya Ogino;Hiroshi Sadamori;Hiroyoshi Matsukawa;Susumu Shinoura;Dong Sheng Sun;Yuzo Umeda;Hiromi Iwagaki;Noriaki Tanaka;Michitaka Ozaki.;Wakatsuki T
• 通讯作者: Wakatsuki T

Thymidine phosphorylase gene mutation is not a primary cause of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)

• DOI: 10.2169/internalmedicine.45.1371
• 发表时间: 2006-01-01
• 期刊: INTERNAL MEDICINE
• 影响因子: 1.2
• 作者: Kumagai, Yukie;Sugiura, Yoshihiro;Yamamoto, Teiji
• 通讯作者: Yamamoto, Teiji

Primary adenocarcinoma of the minor duodenal papilla

原发性十二指肠小乳头腺癌

• 发表时间: 2008
• 期刊: Yonsei Medical Journal 49(2)
• 作者: Wakatsuki;T
• 通讯作者: T