STUDY OF MECHANISMS FOR GRAFT ACCEPTANCE AND ESTABLISHMENT OF STRATEGY IN HUMAN BLOOD TYPE INCOMPATIBLE LIVER TRANSPLANTATION

人血型不相容肝移植的移植接受机制研究及策略制定

• 批准号: 17390350
• 负责人: EGAWA Hiroto
• 金额: $ 9.79万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390350/
• 关键词: C4d; blood type incompatible; liver transplantation; antibody-mediated rejection; B cell phenotype; CD8 positive cell phenotype; anti-CD20 antibody; 血液型不適合移植; リツキシマブ; リンパ球; メモリーB細胞; 抗体価; B細胞; 抗CD 20抗体; 推奨プロトコール

We disclosed the role of compliment and the change of B cell phenotype in antibody mediated rejection in blood type incompatible liver transplantation. Further, we established the strategy to overcome the antibody-mediated rejection using anti-CD-20 antibody and showed the mechanisms of the effects. In order to improve the outcome further, we investigated the role of CD8 positive cells in posttransplant infection, which was the major reason of patient's death after termination of antibody-mediated rejection. We found the significance of dominancy of phenotype of CD8 positive cell in postoperative courses and we are carrying on a prospective study to tailor immunosuppression based on the CD8 positive cell phenotype repertory.

本研究揭示了补体和B细胞表型的改变在血型不合肝移植中抗体介导的排斥反应中的作用。此外，我们建立了使用抗CD-20抗体克服抗体介导的排斥反应的策略，并显示了效果的机制。为了进一步改善预后，我们研究了CD 8阳性细胞在移植后感染中的作用，这是抗体介导的排斥反应终止后患者死亡的主要原因。我们发现CD 8阳性细胞表型在术后病程中占优势的意义，我们正在进行一项前瞻性研究，以根据CD 8阳性细胞表型库定制免疫抑制。

项目成果

Cytotoxic T-cell-mediated defense against infections in human liver transplant recipients

• DOI: 10.1002/lt.21065
• 发表时间: 2007-02-01
• 期刊: LIVER TRANSPLANTATION
• 影响因子: 4.6
• 作者: Tanaka, Koichi;Uemoto, Shinji;Inaba, Kayo
• 通讯作者: Inaba, Kayo

Population pharmacokinetic and pharmacogenomic analysis of Tacrolimus in pediatric living-donor liver transplantation.

他克莫司在儿科活体肝移植中的群体药代动力学和药物基因组学分析。

• 发表时间: 2006
• 期刊: Clin Pharmacolo Ther 80
• 作者: Fukudo M;Yano I;Masuda S;Goto M;Uesugi M;Katsura T;Ogura Y;Oike F;Takada Y;Egawa H;Uemoto S;Inui K
• 通讯作者: Inui K

The role of apheresis therapy for ABO incompatible living donor liver transplantation: The Kyoto University experience

• DOI: 10.1111/j.1744-9987.2006.00409.x
• 发表时间: 2006-10-01
• 期刊: THERAPEUTIC APHERESIS AND DIALYSIS
• 影响因子: 1.9
• 作者: Kozaki, Koichi;Egawa, Hiroto;Takada, Yasutsugu
• 通讯作者: Takada, Yasutsugu

Rapid and Accurate Measurement of Anti-A/B IgG Antibody in ABO-unmatched Living Donor Liver Transplantation by Surface Plasmon Resonance.

通过表面等离子共振快速准确测量 ABO 不匹配活体肝移植中的抗 A/B IgG 抗体。

• 发表时间: 2007
• 期刊: Transfusion Med 7
• 作者: Yamamura K;Ohishi K;Katayama N;et. al.;Yurugi K
• 通讯作者: Yurugi K

Intragraft expression of recipient-type ABO blood group antigens: Long-term follow-up and histological features after liver transplantation

• DOI: 10.1002/lt.20415
• 发表时间: 2005-05-01
• 期刊: LIVER TRANSPLANTATION
• 影响因子: 4.6
• 作者: Tanaka, Y;Haga, H;Manabe, T
• 通讯作者: Manabe, T