Application of Microsphere Including Taclorimus-FK506 to Immunosuppression for Small Bowel Transplantation
他克莫司-FK506微球在小肠移植免疫抑制中的应用
基本信息
- 批准号:12557103
- 负责人:
- 金额:$ 8.26万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2000
- 资助国家:日本
- 起止时间:2000 至 2001
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Rejection remains a major barrier to successful bowel transplantation, despite improved immunosuppressive techniques. New immunosuppressant which has more effect and less side effect is needed. New biodegeneradable microsphere containing Tacrolimus (FK506) was applied to experimental porcine whole small bowel transplantation in which allogenesity between donors and recipients were confirmed by mixed lymphocyte reaction. After transplantation, endoscopic biopsy for histology every 3 days and Tacrolimus (TAC) blood level test daily were performed. Study groups consisted of TAC-0.5mg/kg, TAC-0.2mg/kg, microsphere containing TAC(MS-TAC)0.5mg/kg, MS-TAC0.1mg/kg, MS-TAC0.4mg/kg and MS-TAC0.02mg/kg. Survival period was 9.7, 11.0, 12. 7. 5. 28.6 9.5 days, respectively. TAC trough level was 27.9, 10.9, 60.6, 40.3, 24.6, 10.5, 9.5 ng/ml, respectively. All animals with merely TAC had rejection and 40% of TAC0.5mg/kg had infection. All of MS-TAC0.1, 0.5, 1.0 had no rejection but had infection. Non of MS-TAC0.04 had rejection and infection. Half of MS-TAC0.02 had rejection but not infection. MS-TAC0.04 achieved longer survival and less side effects in this model. MS-TAC has a great potency in immunosuppression with less side effects for small bowel transplantation.
尽管免疫抑制技术有所改进,但排斥反应仍然是肠移植成功的主要障碍。需要一种疗效更好、副作用更少的新型免疫抑制剂。将含有他克莫司的新型生物降解微球(FK506)应用于猪全小肠移植,通过混合淋巴细胞反应证实供受者之间的同种异体。移植后每3天进行一次胃镜活检,每日检测他克莫司(TAC)血药浓度。试验组包括TAC-0.5 mg/kg、TAC-0.2 mg/kg、含TAC微球(MS-TAC)0.5 mg/kg、MS-TAC0.1 mg/kg、MS-TAC0.4 mg/kg和MS-TAC0.02 mg/kg。生存期分别为9.7、11.0、12.7、5、28.6、9.5天。TAC谷值分别为27.9、10.9、60.6、40.3、24.6、10.5、9.5 ng/ml。TAC0.5 mg/kg组有40%的动物发生感染。MS-TAC0.1、0.5、1.0均无排斥反应,但均有感染。MS-TAC0.04无一例发生排斥反应和感染。半数MS-TAC0.02有排斥反应,但无感染。在该模型中,MS-TAC0.04具有较长的生存期和较少的副作用。MS-TAC对小肠移植有较强的免疫抑制作用,且副作用小。
项目成果
期刊论文数量(56)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
上本伸二: "腸管移植"臨床消化器内科. 16・13. 1797-1804 (2001)
植本慎司:《肠移植》临床胃肠病学 16・13(2001 年)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Y.Fujimoto: "Small bowel transplantation using grafts from living-related donors. Two case reports"Transplant International. 13・suppl1. S179-s184 (2000)
Y.Fujimoto:“使用来自活体相关捐赠者的移植物进行小肠移植。两个病例报告”13·suppl1(2000)。
- DOI:
- 发表时间:
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- 影响因子:0
- 作者:
- 通讯作者:
Hideyuki Motohashi: "Expression of peptide transporter following instinal transplantation in the rat"Journal of Surgical Research. 99. 294-300 (2001)
Hideyuki Motohashi:“大鼠肠移植后肽转运蛋白的表达”外科研究杂志。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Y. Fujimoto: "Small bowel transplantation using grafts from living-related donors. Two case reports"Transplant International. 13・Suppl.11. S179-S184 (2000)
Y. Fujimoto:“使用来自活体相关捐献者的移植物进行小肠移植。两个病例报告”《移植国际》13·S179-S184(2000 年)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Tohru Hashida: "Pharmacokinetic and prognostic signifificance of intestinal MDRI expression in recipients of living-donor liver transplantation"Pharmacokinetics and drug disposition. 69・5. 308-316 (2001)
Tohru Hashida:“活体肝移植受者肠道 MDRI 表达的药代动力学和预后意义”药代动力学和药物处置 69・5(2001)。
- DOI:
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- 影响因子:0
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{{ truncateString('EGAWA Hiroto', 18)}}的其他基金
STUDY OF MECHANISMS FOR GRAFT ACCEPTANCE AND ESTABLISHMENT OF STRATEGY IN HUMAN BLOOD TYPE INCOMPATIBLE LIVER TRANSPLANTATION
人血型不相容肝移植的移植接受机制研究及策略制定
- 批准号:
17390350 - 财政年份:2005
- 资助金额:
$ 8.26万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Study of immunological mechanisms during successful withdrawal of immunosuppression after living donor liver transplantation
活体肝移植成功撤除免疫抑制过程中的免疫机制研究
- 批准号:
11470258 - 财政年份:1999
- 资助金额:
$ 8.26万 - 项目类别:
Grant-in-Aid for Scientific Research (B)