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A study on higher-order gait control and its dysfunction using neuroimaging technique

利用神经影像技术研究高阶步态控制及其功能障碍

基本信息

批准号：
17500210
负责人：
HANAKAWA Takashi
金额：
$ 2.37万
依托单位：
National Center of Neurology and Psychiatry
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

The present study aimed at studying neural mechanisms of higher-order gait control and its abnormality, which may lead to gait disorders, by combining multiple non-invasive brain mapping techniques such as neuroimaging and electrophysiology. To begin with, a hypothetical neural mechanism of human gait control was proposed as a theoretical framework of following studies. This model was composed of two fundamental systems: basal ganglia-brainstem system and basal ganglia-thalamo-cortical system. In parallel to this theoretical development, effort was made for the methodological development to subserve the neuroimaging study of gait. These technical developments include the application of functional magnetic resonance imaging(fMRI) on cognitive, linguistic and motor behavior, diffusion tensor imaging(DTI), and simultaneous measurement of transcranial magnetic stimulation(TMS) -electromyography- fMRI. Moreover, the present study yielded two major achievements specific to the understanding … More of gait control. (1) To investigate the visuo-motor interaction in the gait control system, brain activity was investigated with functional magnetic resonance imaging while subjects watched a movie of another person's walking behavior from the third-person perspective or they imagined them walking under the visual environment mimicking visual experience of walking behavior from the first-person perspective. The results revealed that supplementary motor areas and premotor areas were active during both observation and imagination of gait. This study suggests that gait planning centers in the motor cortex are also involved in understanding of other persons' walking behavior. (2) Twenty patients with ischemic white matter changes were classified into 11 patients with gait disorder and 9 patients with normal walking behavior. Blood flow was measured while these patients were walking on a treadmill. The main results were underactivity in the right thalamus and supplementary motor areas in the gait disordered group. Understanding of human gait control system with neuroimaging will be important for the development of neuro-rehabilitation and brain-machine interface. Less

本研究旨在结合神经影像学和电生理学等多种无创性脑标测技术，研究步态高阶控制的神经机制及其异常可能导致的步态障碍。开始，提出了一个假设的人类步态控制的神经机制作为后续研究的理论框架。该模型由两个基本系统组成：基底节-脑干系统和基底节-丘脑-皮质系统。在理论发展的同时，还努力发展方法学，以支持步态的神经影像学研究。这些技术发展包括功能性磁共振成像（fMRI）在认知、语言和运动行为上的应用，扩散张量成像（DTI），以及经颅磁刺激（TMS）-肌电图- fMRI的同时测量。此外，本研究还取得了两项主要成果， ...更多信息步态控制(1)为了研究步态控制系统中的视觉-运动相互作用，当受试者从第三人称视角观看另一个人的步行行为的电影或想象他们在从第一人称视角模仿步行行为的视觉体验的视觉环境下行走时，用功能性磁共振成像研究大脑活动。结果表明，在观察和想象步态过程中，辅助运动区和运动前区均处于活跃状态。这项研究表明，运动皮层中的步态规划中心也参与了对他人步行行为的理解。(2)20例缺血性白色改变患者分为11例步态障碍和9例正常行走行为。当这些患者在跑步机上行走时测量血流量。主要结果是步态障碍组的右侧丘脑和辅助运动区活动不足。利用神经影像学技术了解人体步态控制系统对神经康复和脑机接口的发展具有重要意义。少