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Effect of heat on conduction study of the peripheral nerve : Measuring conduction block and distribution of velocities of the sensory nerve

热对周围神经传导研究的影响：测量感觉神经的传导阻滞和速度分布

基本信息

批准号：
17500371
负责人：
OKAJIMA Yasutomo
金额：
$ 2.53万
依托单位：
Kyorin University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

It is difficult to accurately evaluate sensory disturbance caused by peripheral nerve lesion because of individual difference in perception and emotion related to sensory disturbance and discomfort. It is nevertheless needed in the field of rehabilitation medicine to show therapeutic effects of heat such as microwave and ultrasound on sensory disturbance and discomfort. Mechanism of its efficacy also should be investigated. Thus, we developed a method to indicate sensory nerve function from nerve action potentials obtained during conventional nerve conduction studies. Distribution of sensory nerve conduction velocities and magnitude of conduction block were estimated mathematically by solving so-called inverse problems. We succeeded in noise-reduction of recorded potentials using a glove-shaped ground electrode made of electro-conducting cloth that was necessary for mathematical analysis. Computer simulation studies showed accurate estimation was possible when the noise was less than 30dB and the magnitude of conduction block was less than 50%. Reproducibility and validity of the method was checked in 2 healthy subjects. We could not see waveform changes between recorded potentials before and after application of either microwave or ultrasound in 2 subjects. Therefore, we recorded temperature and potentials while warming arms of the 2 subjects up to 35℃ after iced down to 25℃. Velocities increased with temperature in linear manner at 1-1.3 m/s/℃. Conduction block increased with temperature nearly at the rate of 2-3%/℃ which might yield therapeutic effects of heat. Finally, we showed possible application of this evaluation method for patients with mild diabetic neuropathy.

由于与感觉障碍和不适相关的知觉和情绪的个体差异，准确评估周围神经损伤引起的感觉障碍是很困难的。然而，在康复医学领域，仍需要显示微波和超声波等热对感觉障碍和不适的治疗效果。其疗效机制还需进一步研究。因此，我们开发了一种从常规神经传导研究中获得的神经动作电位来指示感觉神经功能的方法。感觉神经传导速度的分布和传导阻滞的大小是通过求解所谓的逆问题来数学估计的。我们成功地使用了用导电布制成的手套形接地电极来降低记录电位的噪声，这是数学分析所必需的。计算机模拟研究表明，当噪声小于30db，传导阻滞幅度小于50%时，可以进行准确的估计。在2名健康受试者身上检验了该方法的重复性和有效性。2例受试者在应用微波或超声前后均未见记录电位的波形变化。因此，我们记录了两名受试者在冰冻至25℃后，手臂加温至35℃时的温度和电位。流速在1~1.3m/S/℃范围内随温度呈线性增加。传导阻滞随温度升高几乎以2~3%/℃的速度增加，可能产生热疗作用。最后，我们展示了这种评估方法在轻度糖尿病神经病变患者中的可能应用。