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Investigation of modulation of skin vasodilator function by exercise training in a hot environment

高温环境下运动训练对皮肤血管舒张功能调节的研究

基本信息

批准号：
17500453
负责人：
FUMIO Yamazaki
金额：
$ 2.33万
依托单位：
University of Occupational and Environmental Health, Japan
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

Exercise training in a hot environment modulates the controlling system of skin blood flow and sweating, important thermoregulatory functions, in humans. Most of the findings regarding the modulation of skin vasomotor control by exercise training (or heat acclimation) are obtained from studies of nonglabrous (hairy) skin, usually forearm skin, but information about the influence of heat acclimation on glabrous (nonhairy) skin such as the palm is restricted. In this project, we examined the vasomotor responses in the glabrous and nonglabrous skin during whole body heating before and after a 6-day exercise-heat acclimation program. We also examined changes in the control of sweating by heat acclimation by using frequency of sweat expulsion, an index of central sudomotor activity. Eight healthy young volunteers underwent a six-day heat acclimation program [a total of 80-min exercise at 50% peak rate of oxygen consumption in the heat (36℃)]. In the days before and after the heat acclimation program, we examined the local sweating rate at the chest and forearm, frequency of sweat expulsion, and esophageal temperature during whole body heating using a water-perfused suit. As a result, short-term heat acclimation did not change the vascular response in glabrous skin to a raised core temperature but decreased the temperature threshold for vasodilation in nonglabrous skin. It was also suggested that short-term heat acclimation modulates central sudomotor mechanisms, decreasing the temperature threshold for sweating but does not change in the peripheral mechanism for sweating.

炎热环境中的运动训练可以调节皮肤血流和出汗的控制系统，这是人类重要的体温调节功能。大多数关于通过运动训练（或热适应）调节皮肤血管舒缩控制的研究结果都是从无毛（有毛）皮肤（通常是前臂皮肤）的研究中获得的，但有关热适应对无毛（无毛）皮肤（例如手掌）的影响的信息受到限制。在这个项目中，我们检查了在 6 天的运动热适应计划之前和之后全身加热过程中无毛和无毛皮肤的血管舒缩反应。我们还通过排汗频率（中枢催汗活动指数）来检查热适应对出汗控制的变化。 8名健康的年轻志愿者进行了为期6天的热适应计划[在高温（36℃）下以50%耗氧峰值速率进行总共80分钟的运动]。在热习服前后的几天里，我们使用灌水服检查了胸部和前臂的局部出汗率、排汗频率以及全身加热时的食道温度。结果，短期热适应并没有改变无毛皮肤对升高的核心温度的血管反应，但降低了无毛皮肤血管舒张的温度阈值。也有人认为，短期热适应调节中枢催汗机制，降低出汗的温度阈值，但不会改变出汗的外周机制。