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Analysis of mitochondrial DNA in brain tissue in the case of sudden death using micro-dissection system

利用显微解剖系统分析猝死者脑组织中的线粒体DNA

基本信息

批准号：
17590573
负责人：
HONDA Katsuya
金额：
$ 2.46万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

In body fluid such as the blood and the urine, it became clear that blood and the urinary level was closely related to except a case of the renal disease examined about a level distribution of copper, lead, cadmium, zinc, gallium, mercury, antimony, arsenic. The element which was usually not seen was cadmium, and comparatively little element was lead in the blood.Noxious element, such as arsenic and mercury and the antimony, are comparatively included in high concentration in blood and urine, and some kind of useful functions is to be suggested. Also, the gallium are included in comparative high concentration in body fluid, and it is likely that it is associated with a basic life function.Included with relatively high concentration, and it is comparatively interesting in body fluid, the copper considered to be essential element for blood circulation because it seems to be included high concentration than a normal human in the affected patient of circulation.Also, in the case that abnormality was seen in brain tissue, it revealed the change that copper accumulation was big, and heteroplasmic point mutation of the mitochondrial DNA were multiplexed in such case, and it became clear that this grew bigger to an elderly person. As for heteroplasmic point mutations of the mitochondrial DNA were produced at the frequency of about 0.5% from the brain analysis of the healthy human.The cadmium tended to be accumulated in the patient of renal disease, but it became clear for such a case that the degree of the cerebral pathologic change was bigger at the same time. The copper accumulation tended to be accompanied with some kind of pathological changes in a patient with hepatic disorder, but it became clear not to be associated with the accumulation of the lead.

在血液和尿液等体液中，除1例肾脏疾病检查铜、铅、镉、锌、镓、汞、锑、砷的水平分布外，血和尿液中铜、铅、镉、锌、镓、汞、锑、砷的水平分布与血和尿密切相关。通常看不到的元素是镉，血液中的铅元素相对较少，有毒元素如砷、汞和锑在血液和尿液中含量较高，一些有用的功能有待于提出。此外，镓在体液中的浓度相对较高，很可能与基本的生命功能有关。由于铜的浓度相对较高，在体液中相对有趣，因此被认为是血液循环的必要元素，因为在受循环影响的患者中，铜的浓度似乎比正常人高。此外，在脑组织出现异常的情况下，揭示了铜积累较大的变化，线粒体DNA的异质性点突变在这种情况下多种多样，很明显，这种变化对老年人来说变得更大了。正常人脑组织分析发现线粒体DNA异质性突变的频率约为0.5%，肾脏疾病患者体内有镉蓄积的趋势，但病变程度越大，肾脏病变越明显。在肝病患者中，铜的蓄积往往伴随着某种病理变化，但显然与铅的蓄积无关。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Concentration of trace elements in serum and urine of the patients with chronic metabolic syndrome

慢性代谢综合征患者血清和尿液中微量元素浓度

DOI：
发表时间：
2007
期刊：
影响因子：
0
作者：
Kaminiwa;J
通讯作者：
J

Scientific history of life for nursing

护理的科学生命史

DOI：
发表时间：
2007
期刊：
Gendai-sha
影响因子：
0
作者：
Kominato Y;Hata Y;Takizawa H.;Honda K
通讯作者：
Honda K

Outline of medical education(1)

医学教育大纲(1)

DOI：
发表时间：
2006
期刊：
Gendai-sha
影响因子：
0
作者：
Kominato Y;Hata Y;Takizawa H.;Honda K;Segho T;Tanaka E;Tanaka E;Tanaka E;Ito T;Terada M;中西修平;Osaka Y;Segho T
通讯作者：
Segho T

Concentration of trace elements(Cd, Pb, Cu, Zn)in serum and urine of the patients with chronic metabolic syndrome

慢性代谢综合征患者血清和尿液中微量元素(Cd、Pb、Cu、Zn)浓度