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Effect of Lifestyle-related factors on developing end-stage renal disease (ESRD)

生活方式相关因素对终末期肾病（ESRD）发展的影响

基本信息

批准号：
17590835
负责人：
ISEKI Kunitoshi
金额：
$ 1.18万
依托单位：
University of the Ryukyus
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17590835/
关键词：
Chronic kidney disease end-stage renal disease proteinuria metabolic syndrome obesity Dialysis Life style

项目摘要

Effect of Lifestyle-related factors on developing end-stage renal disease (ESRD)There will be more than 2 million dialysis patients in the world by 2010, approximately 0.3 million in Japan alone. Community-based screening programs have provided data for several papers on this topic. Among them, the Okinawa General Health Maintenance Association, a nonprofit organization founded in 1972, conducts an annual large community-based health examination screening program. Approximately 14% of the total adult population of Okinawa participated in each screening. The ESRD patient registry in Okinawa was used to investigate the outcome of the screenees. All chronic dialysis patients residing in the prefecture who survived for at least 1 month on scheduled dialysis were included in the registry. All patients (n=5246) were followed-up until the occurrence of a major medical event or until January 2001, whichever occurred first, and all outcomes were verified.Using the two registries, we identified … More screening participants who later entered a dialysis program. Furthermore, patient data were verified by medical records. Important predictors of developing ESRD are dipstick・positive proteinuria and hypertension. Low GFR per se, which is often observed in the elderly population, is not a strong predictor of developing ESRD unless associated with proteinuria. Other significant risk factors are obesity and metabolic syndrome. Both the prevalence and incidence of CKD increase with an increase in the number of components of metabolic syndrome. The relationship between baseline BMI and the cumulative incidence of ESRD is linear, particularly in men, but a similar trend in both men and women has been reported.Incidence and prevalence of CKD are closely related with the lifestyle such as diet, exercise, tobacco, and other cultural differences. Research on the relationship between CKD and metabolic syndrome may provide clue to understand better the role of lifestyle related factors and the age-related decline in GFR. Early detection and treatment of metabolic syndrome would be one of the cost-effective strategy for ever increasing prevalence of ESRD. Therefore, subjects with metabolic syndrome are candidates for the screening of CKD through dipstick proteinuria and measurement of serum creatinine. Less

生活方式相关因素对终末期肾病（ESRD）发展的影响到2010年，全世界将有超过200万透析患者，仅日本就有大约30万。以社区为基础的筛查项目为这一主题的几篇论文提供了数据。其中，成立于1972年的非营利组织冲绳综合健康维护协会（Okinawa General Health Maintenance Association）每年都会开展大型社区健康检查筛查项目。约有14%的冲绳成年人口参加了每次筛查。冲绳县ESRD患者登记处被用来调查筛选者的结果。所有居住在该县并在计划透析中存活至少1个月的慢性透析患者均被纳入登记。对所有患者（n=5246）进行随访，直到发生重大医疗事件或直到2001年1月，以先发生者为准，并对所有结果进行验证。通过这两个登记，我们发现…更多的筛查参与者后来进入了透析计划。此外，还通过医疗记录核实了患者数据。尿试纸阳性蛋白尿和高血压是发生ESRD的重要预测因素。低GFR本身，通常在老年人群中观察到，除非与蛋白尿相关，否则不是发生ESRD的有力预测因素。其他重要的危险因素是肥胖和代谢综合征。CKD的患病率和发病率都随着代谢综合征组成部分数量的增加而增加。基线BMI与ESRD的累积发病率之间的关系是线性的，尤其是在男性中，但在男性和女性中也有类似的趋势。CKD的发病和流行与生活方式如饮食、运动、吸烟等文化差异密切相关。研究CKD与代谢综合征之间的关系，可以为更好地理解生活方式相关因素在GFR年龄相关性下降中的作用提供线索。早期发现和治疗代谢综合征将是一个具有成本效益的策略，为日益增加的ESRD患病率。因此，代谢综合征患者是通过尿量尺检测蛋白尿和测定血清肌酐筛查CKD的候选者。少