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Estimation of pulmonary hypertension by measurement of flow profile of pulmonary artery with CineMRI

通过 CineMRI 测量肺动脉血流剖面来评估肺动脉高压

基本信息

批准号：
17591283
负责人：
MURAYAMA Sadayuki
金额：
$ 2.28万
依托单位：
University of the Ryukyus
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591283/
关键词：
cineMRI pulmonary artery blood flow pulmonary fibrosis interstisial pneumonia pulmonary hypertention MRA 肺動脈流速肺高血 cine MRA

项目摘要

We measured pulmonary blood flow with phase contrast MRI for 20 volunteers and evaluated precision and reproducible of two slice positions, that is, perpendicular to pulmonary trunck and not, We detected a method to determine the slice which was perpendicular to a pulmonary artery, and reported that precision and reproducibility is higher with perpendicular slicesBased on this preliminary study, we examined whether pulmonary artery blood flow and other data were useful in an evaluation of the pulmonary hypertension. The subjects were ten patients with pulmonary fibrosis (they were thought that pulmonary arterial pressure was elevated) and ten healthy people. We measured pulmonary artery blood flow and calculated an index of some pulmonary hypertension; acceleration time (AT), acceleration volumes (AV), ratios M to AV (M: maximal change in flow rate during ejection), distensibility (Dis), average flow (Aveflo) and compared healty persons and the patient with pulmonary fibrosis. Respiratory function test was performed to the patients and evaluated the correlation with the indices. Almost all indices were significantly different between patients and volunteers. ROC analysis showed high capability of indices to discriminate patients from healthy volunteers. These results show that phase contrast MRI is a useful technique to evaluate elevation of the pulmonary arterial pressure. Compared indices with respiratory function test results, Dis, Aveflo showed a good correlation with severity of the pulmonary fibrosis. This suggests that these indexes reflected the distal pulmonary change, i. e. fibrosis, better than pulmonary arterial pressure. Additional investigations are necessary to confirm these results

我们对20名志愿者的肺血流进行了相位对比MRI测量，并对垂直于肺动脉干和不垂直于肺动脉干两种切片位置的精度和可重复性进行了评价。我们发现了一种确定垂直于肺动脉的切片的方法，并报告了垂直切片的精度和可重复性更高。我们检查了肺动脉血流量和其他数据是否对肺动脉高压的评估有用。研究对象是10名肺纤维化患者（他们被认为是肺动脉压升高）和10名健康人。我们测量了肺动脉血流量并计算了一些肺动脉高压的指数；加速时间（AT）、加速体积（AV）、M / AV之比（M：射血时最大流速变化）、扩张性（Dis）、平均流量（Aveflo），并将健康人与肺纤维化患者进行比较。对患者进行呼吸功能检查，并评价其与各项指标的相关性。几乎所有指标在患者和志愿者之间都有显著差异。ROC分析显示，这些指标对患者和健康志愿者有较高的区分能力。这些结果表明，MRI相衬是一种有效的评估肺动脉压升高的技术。与呼吸功能试验结果比较，Dis、Aveflo与肺纤维化严重程度有较好的相关性。这说明这些指标比肺动脉压更能反映肺远端变化，即纤维化。需要进一步的调查来证实这些结果