Evaluation of hemodynamic changes in pulmonary and systemic arterial circulation with special attention to shunt volume in patients with pulmonary fibrosis using phase contrast MRI.

使用相差 MRI 评估肺和全身动脉循环的血流动力学变化，特别注意肺纤维化患者的分流量。

• 批准号: 21591570
• 负责人: MURAYAMA Sadayuki
• 金额: $ 2.91万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591570/
• 关键词: 肺高血圧; MRI; Velocity-encoded cine MRI; 肺動脈血流; cine MRA; 肺線維症; 肺動脈血流量

Using PC-MRI, we calculated various indexes of the pulmonary blood flow of the patients that pulmonary hypertension should have been suspected and examined correlation with the echocardiographic tricuspid gradient. As a result, an average area of the pulmonary artery truncus, minimum area, and a maximal area a were well correlated with tricuspid gradient. It was minimum area to have been the strongest in a correlation ;(coefficient of correlation 0. 772 ; p=0. 001). Secondly, an aortic and pulmonary arterial flow by PC-MRI for normal volunteers and patients with interstitial pneumonia were calculated both during free breathing and respiratory breath-holding. Both flow significantly decreased in normal volunteers and patients. However, in patients, no significant reduction under the breath-holding nor increase of bronchopulmonary shunt were observed.

我们利用PC-MRI计算了肺动脉高压疑似患者肺血流的各项指标，并与超声心动图三尖瓣梯度进行了相关性分析。肺动脉干的平均面积、最小面积和最大面积a与三尖瓣梯度有很好的相关性。这是最小面积的相关性最强；(相关系数0。772年;p = 0。001)。其次，计算正常志愿者和间质性肺炎患者在自由呼吸和呼吸屏气时的PC-MRI主动脉和肺动脉流量。在正常志愿者和患者中，这两种血流都明显减少。然而，在患者中，未观察到屏气下的明显减少或支气管肺分流的增加。

项目成果

Evaluation of Hemodynamic Changes in Pulmonary and Systemic Arterial Circulation in Patients with Pulmonary Fibrosis in Relation to Breathing Methods Using. Phase Contrast MRI

评估肺纤维化患者肺动脉和体动脉循环的血流动力学变化与呼吸方法的关系。

• 发表时间: 2011
• 作者: Nanae Tsuchiya;Yuichiro Ayukawa;Sadayuki Murayama
• 通讯作者: Sadayuki Murayama

Estimation of pulmonary vascular resistance in patients with pulmonary fibrosis by phase-contrast magnetic resonance imaging

相衬磁共振成像评估肺纤维化患者的肺血管阻力

• 发表时间: 2011
• 期刊: Japanese Journal of Radiology
• 影响因子: 2.1
• 作者: 神田知紀;吉川武;大野良治;小西稔;前田哲雄;北島一宏;神山久信;竹中大祐;杉村和朗;Yuichiro Ayukawa
• 通讯作者: Yuichiro Ayukawa

Evaluation of hemodynamic changes in pulmonary and systemic arterial circulation in patients with pulmonary fibrosis in relation to breathing methods using phase contrast MRI

使用相差 MRI 评估肺纤维化患者肺和体动脉循环血流动力学变化与呼吸方法的关系

• 发表时间: 2011
• 作者: Yamada Y;Mori H Matsumoto S;Fujiya N;Hongo N;Moriyama M;土屋奈々絵
• 通讯作者: 土屋奈々絵

PHASE CONTRAST MRIによる肺線維症患者の肺動脈圧の評価

相衬MRI评估肺纤维化患者的肺动脉压

• 发表时间: 2010
• 作者: 小林晋;原眞咲;荒川利直;他;立石宇貴秀;鮎川雄一郎
• 通讯作者: 鮎川雄一郎