Evaluation of hemodynamic changes in pulmonary and systemic arterial circulation with special attention to shunt volume in patients with pulmonary fibrosis using phase contrast MRI.

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Using PC-MRI, we calculated various indexes of the pulmonary blood flow of the patients that pulmonary hypertension should have been suspected and examined correlation with the echocardiographic tricuspid gradient. As a result, an average area of the pulmonary artery truncus, minimum area, and a maximal area a were well correlated with tricuspid gradient. It was minimum area to have been the strongest in a correlation ;(coefficient of correlation 0. 772 ; p=0. 001). Secondly, an aortic and pulmonary arterial flow by PC-MRI for normal volunteers and patients with interstitial pneumonia were calculated both during free breathing and respiratory breath-holding. Both flow significantly decreased in normal volunteers and patients. However, in patients, no significant reduction under the breath-holding nor increase of bronchopulmonary shunt were observed.