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Studies on the improvement of prognosis in twin pregnancies

改善双胎妊娠预后的研究

基本信息

批准号：
17591709
负责人：
MINAKAMI Hisanori
金额：
$ 2.28万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

It is important for all obstetrician-gynecologists to realize or know the vital statistics of worth prognosis of twin pregnancies in improving the prognosis of twin pregnancies. We started the system of registration of twin pregnancies diagnosed before 15^<th> week of gestation in Hokkaido in Apr. 2005. At the end of March, 2007, 339 women with twin pregnancies were enrolled and registered. Of 339 twin pregnancies, 235(69.3%) 97(28.6%), and 4(1.2%) were dichorionic diamniotic, monochorioic diamniotic, and monochorionic monoamniotic, respectively, after excluding 3 cases with unknown chorionicity. Twin pregnancies established after treatment for infertility accounted for 125(36.9%) cases, including 61 cases after IVF-ET, 35 cases after clomiphene citrate, and 29 after hMG-hCG. Thus, it was clarified that an approximately one third of twin pregnancies were established after treatment of infertility in current Hokkaido. Gestational age at deliveries was known in 168 cases. Preterm deliveries before 33 weeks of gestation occurred more frequently in monochorionic twins than in dichorionic twins (9/46 [19.6%] vs. 11/122 [9.0%] These figures were apparently worse compared with that of an approximately 0.8% of singleton pregnancies. Because these information on the results of analysis were released to all obstetricians-gynecologists participating in this registration system, early referral of twin pregnancies to the secondary or tertiary hospitals appeared to be promoted after the establishment of this system, These movement may contribute to improve the prognosis of twin pregnancies in Hokkaido.

了解双胎妊娠预后价值的重要指标，对提高双胎妊娠的预后有重要意义。我们于2005年4月在北海道启动了妊娠15周前诊断的双胎妊娠登记制度<th>。截至2007年3月底，共有339名双胎妊娠妇女参加并登记。在339例双胎妊娠中，排除3例不明绒毛膜情况后，分别为绒毛膜双羊膜腔235例（69.3%）、单绒毛膜双羊膜腔97例（28.6%）和单绒毛膜单羊膜腔4例（1.2%）。不孕症治疗后双胎妊娠125例（36.9%），其中IVF-ET 61例，克罗米芬35例，hMG-hCG 29例。因此，澄清了目前北海道约三分之一的双胞胎妊娠是在治疗不孕症后确定的。在168个案例中，已知分娩时的怀孕年龄。单绒毛膜双胎妊娠33周前早产的发生率高于双绒毛膜双胎（9/46 [19.6%] vs. 11/122 [9.0%]）。由于这些分析结果的信息被发布给参与该登记系统的所有妇产科医生，因此在该系统建立后，似乎促进了双胞胎妊娠早期转诊到二级或三级医院，这些运动可能有助于改善北海道双胞胎妊娠的预后。