The systemic effects of experi, emtally induced periodontitis in rats

实验性诱发大鼠牙周炎的全身效应

基本信息

  • 批准号:
    17591983
  • 负责人:
  • 金额:
    $ 2.35万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2005
  • 资助国家:
    日本
  • 起止时间:
    2005 至 2007
  • 项目状态:
    已结题

项目摘要

In recent years, some evidence has been presented that serum antibody titer against Porphyromonas gingivalis (Pg), cholesterol, triglyceride and blood glucose level were significantly higher in patients with periodontal disease than in healthy subjects. Thus, it is suggested that periodontal disease could influence the metabolism of lipids and glucose. This study examined the effects of experimentally induced periodontitis on the serum level of triglyceride, glucose, TNF- α, IL-6, C-reactive protein (CRP) and adiponectin in rats.Forty-eight male Wistar rats fed high-sucrose or high-fat diet were divided into Pg-infected groups or control groups. Experimental periodontitis was induced by applying a small elastic ring around the mandibular first molar (Ml) in Pg-infected groups. After one week, Pg soaked silk sutures were inserted into periodontal pockets and fixed by elastic rings around M1 of the rats in the Pg-infected groups. After four weeks, rats were sacrificed by drawing blood from the hearts and removed mandibular bones. Rats of control groups were not treated and maintained for 5 weeks.Significant alveolar bone loss was found in the Pg-infected groups compared with that in the control groups. However, there was no significant difference between rats fed high-sucrose diet and those fed high-fat diet. With regard to the serum levels of triglyceride and glucose, there were no significant differences between Pg-infected and control groups. All of the TNF-α, IL-6, CRP and adiponectin levels of the Pg-infected group were under those of the control level, although there were no significant differences.Further studies are needed to determine the effects of diet on the systemic response to Pg infection of the periodontium.
近年来,有证据表明牙周病患者血清抗牙龈卟啉单胞菌(Pg)抗体滴度、胆固醇、甘油三酯和血糖水平明显高于健康人群。因此,我们认为牙周病可能影响脂质和葡萄糖的代谢。本研究探讨实验性牙周炎对大鼠血清甘油三酯、葡萄糖、TNF- α、IL-6、c反应蛋白(CRP)和脂联素水平的影响。48只雄性Wistar大鼠饲喂高糖或高脂饲料,分为pg感染组和对照组。在pg感染组的下颌第一磨牙(Ml)周围应用小弹性环诱导实验性牙周炎。1周后,将Pg浸泡的丝缝线插入牙周袋内,在Pg感染组的M1周围用弹力环固定。四周后,通过从心脏抽血和移除下颌骨来处死大鼠。对照组大鼠不治疗,维持5周。与对照组相比,pg感染组出现明显的牙槽骨丢失。然而,高糖饮食和高脂肪饮食的大鼠之间没有显著差异。至于血清甘油三酯和葡萄糖水平,在pg感染组和对照组之间没有显著差异。pg感染组TNF-α、IL-6、CRP、脂联素水平均低于对照组,但差异无统计学意义。需要进一步的研究来确定饮食对牙周组织对Pg感染的全身反应的影响。

项目成果

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ITAGAKI Yumi其他文献

ITAGAKI Yumi的其他文献

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{{ truncateString('ITAGAKI Yumi', 18)}}的其他基金

Changes of Serum Lipid Levels induced by Periodontal Infection in Rats
牙周感染引起的大鼠血清脂质水平的变化
  • 批准号:
    14571809
  • 财政年份:
    2002
  • 资助金额:
    $ 2.35万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Bacteriological and Clinical Study of Bacteremia due to Periapical Lesion
根尖周病变所致菌血症的细菌学及临床研究
  • 批准号:
    11671892
  • 财政年份:
    1999
  • 资助金额:
    $ 2.35万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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探索牙龈卟啉单胞菌在口腔上皮发育不良中的作用
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脂质A修饰在牙龈卟啉单胞菌发病机制中的调控及影响
  • 批准号:
    10502017
  • 财政年份:
    2022
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    $ 2.35万
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Uncovering the roles of phages in the ecology of Porphyromonas gingivalis in periodontal disease
揭示噬菌体在牙周病牙龈卟啉单胞菌生态学中的作用
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