Mass spektrometer with electrospray ionisation

具有电喷雾电离功能的质谱仪

• 批准号: 534960138
• 金额: --
• 依托单位: Carl von Ossietzky Universität Oldenburg
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/534960138?language=en
• 关键词: Mass; spektrometer; electrospray; ionisation

We apply for a high-resolution mass spectrometer with electrospray ionization (ESI-MS) and a quadrupole orbitrap analyzer for operation in MS/MS mode. In addition to the associated EDV, an HPLC is requested as a peripheral device, which enables the measurement of LC-MS spectra. The complete package also includes a nitrogen generator required for ESI operation (since supply via compressed gas cylinders would be uneconomical at high flow rates), an uninterruptible power supply (USV, due to frequent unplanned and planned power shutdowns in the building) and noise insulation for the vacuum pump. The device applied for is used exclusively in research for the mass spectrometric analysis of organic and inorganic molecular compounds, which are usually new synthetic products. In addition, LC-MS coupling is required to investigate complex product or reaction mixtures in order to identify products and by-products, which can be used, for example, to optimize the reaction or to establish reaction mechanisms. MS/MS coupling is required to elucidate the structure (constitution) of unexpected and unknown compounds (possibly from mixtures using LC-MS).

我们申请了一个高分辨率质谱仪与电喷雾电离（ESI-MS）和四极轨道阱分析仪在MS/MS模式下运行。除了相关的EDV外，还要求将HPLC作为外围设备，以实现LC-MS光谱的测量。整套设备还包括ESI运行所需的氮气发生器（因为在高流速下通过压缩气瓶供应是不经济的）、不间断电源（USV，由于建筑物内频繁的计划外和计划内断电）和真空泵的隔音装置。申请的设备专门用于有机和无机分子化合物的质谱分析研究，这些化合物通常是新的合成产品。此外，需要LC-MS耦合来研究复杂的产物或反应混合物，以鉴定产物和副产物，其可用于例如优化反应或建立反应机理。需要MS/MS偶联来阐明非预期和未知化合物（可能来自使用LC-MS的混合物）的结构（组成）。