500 MHz-NMR-Spektrometer with nitrogen-cooled inverse CryoProbe head

在萨尔兰大学，有机化学和药剂系(用户社区核磁共振)的几个小组参与了复杂天然产物的分离和全合成。结构鉴定通常通过高分辨率质谱学和核磁共振波谱的组合来完成。最后一种技术不仅对结构阐明至关重要，而且对于确定天然产品中广泛存在的立体产生中心的构型也是必不可少的。此外，还将研究天然产物或潜在药物与其生物目标的结合研究(STD-核磁共振)。有了现代反向低温探头技术，光谱仪的灵敏度可以显著提高，如果只有小样本探头可用，这一点很重要。所要求的反向探针头对1H核特别敏感，这对结构和构型确定至关重要。到目前为止，用户社区还没有这样的探头。出于经济原因，我们申请了氮气冷却而不是氦气冷却的探头。所要求的光谱仪是用来替代已有25年历史的500 MHz光谱仪的，后者必须在适当的时候进行更换。它所在的建筑将于今年夏天被拆除，由于其无屏蔽的磁铁，不可能在其他地方运行它。此外，软件完全过时，备件不再可用。

At Saarland University several groups from the department of Organic Chemistry and Pharmacy (user community NMR) are involved in the isolation and total synthesis of complex natural products. Structure elucidation is generally accomplished via a combination of high resolution mass spectrometry and NMR spectroscopy. The last technique is essential not only for structure elucidation but also for the determination of the configuration of stereogenic centers, widespread found in natural products. In addition, binding studies of natural products or potential drugs towards their biological targets will be investigated (STD-NMR). With modern inverse cryoprobe technique the sensitivity of the spectrometer can be increased significantly, what is important if only small sample probes are available. The requested inverse probe head is especially sensitive for 1H nuclei, what is essential for structure and configuration determination. Such a probe head is not available to the user community so far. For reasons of economy we apply for a nitrogen- and not a helium-cooled probe head.The requested spectrometer is a substitution for a 25 year old 500 MHz spectrometer, which has to be replaced in due course. The building where it is located will be teared down this summer, and because of its unshielded magnet there is no possibility the run it somewhere else. In addition, software is completely obsolete and spare parts are not available any more.