The neural bases of decision-making

决策的神经基础

• 批准号: DP200103401
• 负责人: Prof Bernard Balleine
• 金额: $ 93.24万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-06-30 至 2025-07-01
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200103401
• 关键词: neural; bases; decision; making

The aim of this project is to understand the brain circuits controlling voluntary or goal-directed actions and particularly the memory processes that contribute to such actions. Goal-directed action is a fundamental capacity necessary for normal decision-making that is significantly attenuated by normal aging. This project aims to establish the neural circuits engaged in encoding new goal-directed actions, how this encoding is accomplished without interfering with pre-existing memories and how these memories are later retrieved to guide planning and performance. Understanding the determinants of such actions will enable the development of novel ways to treat ageing-related deficits in decision-making with significant economic benefits.

该项目的目的是了解控制自愿或目标行动的大脑电路，尤其是有助于此类行动的记忆过程。目标指导的行动是正常决策所必需的基本能力，这会因正常衰老而大大减弱。该项目旨在建立参与编码新目标指导动作的神经回路，如何完成该编码的情况，而无需干扰预先存在的记忆以及后来如何检索这些记忆来指导计划和绩效。了解此类行动的决定因素将使新的方法开发出具有重大经济利益的决策中与老年相关的赤字。