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Early screening of myocardial injury and lethal arrhythmia by 64-channel magnetocardiography and genetical predisposition

64道心磁图及遗传易感性早期筛查心肌损伤和致死性心律失常

基本信息

批准号：
18500383
负责人：
NAKAI Kenji
金额：
$ 2.59万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

The aim of this study is to develop an early screening of myocardial damage and lethal arrhythmia by 64 channel Magnetocardiography (64-chMCG) and to analyze its genetical predisposition for avoiding side effect by chemotherapy.Results :1. We developed a three-dimensional RTc dispersion map for detecting early myocardial injury and three-dimensional spectral map by 64-ch MCG (Nakai, et. al. Int J Card Imaging, 2006)).2. We developed a three-dimensional spectral map of atrial fibrillation who received adjunctive pulmonary isolation followed by valve replacement. The mean frequency by three-dimensional spectral map by 64-ch MCG could demonstrate a pre-operative value for PV isolation (Nakai, et. al. ; J Electrocardiol, 2008)3. We analyzed the C677T polymorphism of 5, 10'-methylenetrtrahydroforate reductase (5, 10'-MTHFR) in 15 patients with bladder tumor who received a combined MVAC chemotherapy. Obara, et al. reported that C677T polymorphism related the effect and acquired capacity of Methotrexate by a MVAC therapy (Obara, et al. 2007).4. We reported the significance of ethnic differences in the VKORC1 gene polymorphism and an association with warfarin dosage requirements in patients with cardiovascular surgery. (Pharmacogenomics, 2007).5. We developed the 187-ch signal-averaged vector-projected ECG (SAVP) depend on the algorithm of 64-ch MCG for detecting lethal arrhythmia and injured myocardial repolarization (Nakai, et al. Int Heart J, 2007).In conclusion, we developed a 64-ch MCG and 187-ch SAVP ECG and verified the clinical significance for detecting myocardial injury and lethal arrhythmia. We also demonstrated the utility of SNPs as an individualized therapy for predisposition for drug metabolism.

本研究的目的是建立64通道心脏磁图（64- chmcg）早期筛查心肌损害和致死性心律失常，并分析其遗传易感性，以避免化疗的副作用。结果:1。我们开发了用于检测早期心肌损伤的三维RTc弥散图和64-ch MCG的三维光谱图（Nakai等，Int J Card Imaging, 2006）。我们开发了心房颤动的三维频谱图谁接受辅助肺隔离后瓣膜置换术。64-ch MCG三维频谱图的平均频率可以显示PV隔离的术前价值（Nakai等人；J Electrocardiol, 2008）3。我们分析了15例接受MVAC联合化疗的膀胱肿瘤患者的5,10 '-亚甲基四氢甲酸还原酶（5,10 '-MTHFR）的C677T多态性。Obara等人报道C677T多态性与MVAC治疗甲氨蝶呤的效果和获得能力有关（Obara等人，2007）。我们报道了心血管手术患者中VKORC1基因多态性的种族差异的意义以及与华法林剂量需求的关联。(药物基因组学,2007)。5。我们基于64-ch MCG算法开发了187-ch信号平均矢量投影ECG (SAVP)，用于检测致死性心律失常和损伤心肌复极（Nakai等）。国际心脏杂志，2007)。总之，我们研制了64-ch MCG和187-ch SAVP心电图，验证了检测心肌损伤和致死性心律失常的临床意义。我们还证明了snp作为药物代谢易感性的个体化治疗的效用。