The relation of leg venous function and structure to orthostatic hypotension in humans

腿部静脉功能和结构与人体直立性低血压的关系

• 批准号: 18500554
• 负责人: MIURA Akira
• 金额: $ 2.41万
• 依托单位: Prefectural University of Hiroshima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18500554/
• 关键词: orthostatic hypotension; venous compliance; capillary filtration; endurance training; 起立耐性; 下腿静脈コンプライアンス; 膝窩静脈コンプライアンス; 静脈血管収縮

BACKGROUND AND PURPOSE: Despite extensive investigation, the effects of either cardiovascular fitness or age on orthostatic remain uncertain. Calf venous compliance may be a critical factor in determining the cardiovascular stress associated with change in orthostasis. Preventing fluid shifts into the legs markedly reduces reflex responses to an orthostatic stressor. The extent to which exercise training in a previously sedentary older and young population will affect venous compliance and tolerance to the orthostatic stress is unknown. An evaluation of the compliance of the whole venous system (including venule to large vein) in human calf was developed with a venous congested plethysmography (VCPG) (Halliwill, et al., J.Appl.Physiol. 1999) which has already been used in several application studies. Utilizing the B-mode ultrasonography (US), we have proposed a similar technique for estimating the compliance in medium venous vessels (i.e., Popliteal vein) using US images, which is deri … More ved from the CSA-venous pressure (Pv) relationship.Therefore, we investigate:1. The relation of leg venous compliance to orthostatic intolerance in humans.2. Effect of 10days successive endurance training on leg venous compliance.Secondly, to clearly define the venous vascular function concerning venous pooling, we examined:3. The effect of ischemic handgrip exercise on leg venous compliance in humans4. The relationship between venous compliance and capillary filtration in the lower limb.RESULT: Venous compliance was not different between tolerance and intolerance group. This result suggested that the leg venous compliance is not dominant determinant of the orthostatic intolerance in humans. Venous pooling decreases cardiac filling pressure and blood pressure (BP); therefore, arterial baroreceptors (carotid and aortic) and baroreceptors in the cardiopulmonary region must adapt to maintain BP over a fairly wide range of hemodynamic conditions. And no change in calf venous compliance was found after 10 days successive of endurance training (60 min, 40% peak Vo2). Under the sympathetic stimulation (sympatho-excitatory stimulation) induced by the ischemic handgrip exercise to fatigue followed post-exercise ischemia. Compared to the control, the calf volume was consistently smaller under the sympathetic stimulation. The venous compliance at lower Pv was significantly lower. These data shows to existence of sympathetic venous vascular regulation in humans. In addition, there is negative correlation was observed between venous compliance and capillary filtration in the lower limb. Less

背景和目的：尽管进行了广泛的研究，心血管健康或年龄对立位力的影响仍然不确定。小腿静脉顺应性可能是决定与体位改变相关的心血管应激的关键因素。防止液体转移到腿部明显减少了对直立性应激源的反射反应。运动训练在多大程度上会影响以前久坐的老年人和年轻人的静脉顺应性和耐力的立位应力是未知的。用静脉充血体积描记法（VCPG）（Halliwill等人，J.Appl. Physiol.1999），其已经用于若干应用研究中。利用B型超声（US），我们提出了一种类似的技术，用于估计中等静脉血管（即，腘静脉）使用US图像，这是由于 关于我们 从CSA与静脉压（Pv）的关系中得出，因此，我们研究：1。下肢静脉顺应性与人体立位耐力的关系.连续10天耐力训练对下肢静脉顺应性的影响第二，为了明确静脉血池的血管功能，我们研究了：3。缺血性握力训练对人体下肢静脉顺应性的影响4。下肢静脉顺应性与毛细血管滤过的关系结果：耐受组与不耐受组静脉顺应性无差异。提示下肢静脉顺应性不是人体立位耐力不良的主要决定因素。静脉汇集降低心脏充盈压和血压（BP）;因此，动脉压力感受器（颈动脉和主动脉）和心肺区域的压力感受器必须适应在相当宽的血液动力学条件下维持BP。连续10天的耐力训练（60 min，40%Vo2峰值）对小腿静脉顺应性无明显影响。在缺血性握力运动诱发的交感神经刺激（交感神经兴奋性刺激）作用下，运动后出现缺血性疲劳。与对照组相比，在交感神经刺激下，小腿体积始终较小。较低Pv时的静脉顺应性显著降低。这些数据表明人类存在交感静脉血管调节。下肢静脉顺应性与毛细血管滤过率呈负相关。少

项目成果

Central circulatory and peripheral 02 extraction change as interactive facilitators of pulmonary 02 uptake during a repeated high-intensity exercise protocol in humans

在人类重复高强度运动方案中，中枢循环和外周 02 提取变化作为肺 02 摄取的交互促进剂

• 发表时间: 2007
• 期刊: European Journal of Applied Physiology 99
• 作者: Yoshiyuki;Fukuba;Masako;Yamaoka;Endo;Yukie;Ohe;Yuiko;Hirotoshi;Asami;Kitano;Chiaki;Shiragiku;Akira;Miura;Osamu;Fukuda;Hatsmi;Ueoka;Motohiko;Miyachi
• 通讯作者: Miyachi

Thigh muscle activation distribution and pulmonary Vo2 kinetics during mod crate,heavy,and very heavy cycling exercise in humans

人类现代板条箱、重型和超重型自行车运动期间大腿肌肉激活分布和肺 Vo2 动力学

• 发表时间: 2007
• 期刊: Am.J.Appl.Physiol 293
• 作者: Masako Endo;Mayumi Kobayakawa;Ryuta Kinugasa;Shinya kuno;Hiroshi Akima;Harry B.Rossiter;Akira Miura;Yoshiwki Fukuba
• 通讯作者: Yoshiwki Fukuba

Thigh muscle activation distribution and pulmonary Vo2 kinetics during moderate, heavy, and very heavy cycling exercise in humans

人类中度、重度和极重度自行车运动期间大腿肌肉激活分布和肺 Vo2 动力学

• 发表时间: 2007
• 期刊: American Jurnal of Applied Physiology 293
• 作者: Masako;Endo;Mayumi;Kobayakawa;Ryuta;Kinugasa;Shinya;kuno;Hiroshi;Akima;Harry B.;Rossiter;Akira;Miura;Yoshivuki;Fukuba
• 通讯作者: Fukuba

Measurement of popliteal venous compliance with an ultrasonography

超声检查测量腘静脉顺应性

• 发表时间: 2006
• 作者: A Miura;A Tsumura;M Ide;M Urabe;H Ueoka;M Endo;and Y Fukuba
• 通讯作者: and Y Fukuba

Central circulatory and peripheral O2 extraction change as interactive facilitatorsof pulmonary O2 uptake during a repeated high-intensity exercise protocol in humans

在人类重复高强度运动方案中，中央循环和外周 O2 提取变化作为肺 O2 摄取的交互促进剂

• 发表时间: 2007
• 期刊: Eur.J.Appl.Physiol 90
• 作者: Yoshiyuki Fukuba;Masako Yamaoka Endo;Yukie Ohe;Yuiko Hirotoshi;Asami Kitano;Chiaki Shiragiku;Akira Miura;Osamu Fukuda;Hatsmi Ueoka;Motohiko Miyachi
• 通讯作者: Motohiko Miyachi