Aerobic Oxidation Reactions Catalyzed by Flavin Molecules

由于分子氧和有机催化剂的易得性和安全性，有机催化好氧氧化法是最具吸引力的方法之一。在这个项目中，作者开发了高选择性和环境友好的杂原子化合物的氧化以及基于黄素促进的分子氧活化的烯烃加氢方法.肼容易被黄素阳离子催化的有氧氧化反应氧化，得到二氮烯，它是一种对不饱和键具有高活性的氢供体。利用该系统开发了不使用金属催化剂和氢气的环境友好的烯烃加氢方法.以二氨基吡啶为核的树枝状大分子通过三点氢键作用与黄素分子结合形成黄素-树枝状大分子复合物。由于催化剂周围的疏水环境，配合物表现出较高的催化性能.以二氨基吡啶为核的树枝状大分子通过三点氢键作用与黄素分子结合形成黄素-树枝状大分子复合物。由于催化剂周围的疏水环境，配合物表现出较高的催化性能.金纳米颗粒可以被黄素分子功能化。黄素功能化金纳米粒子可作为硫化物有氧氧化和烯烃有氧加氢的催化剂。

Organocatalytic aerobic oxidation is one of the most attractive methods because of availability and safety of molecular oxygen and organocatalysts. In this project, the author developed highly selective and environmentally friendly methods for oxidation of heteroatom compounds as well as hydrogenation of olefins based on the flavin-promoted activation of molecular oxygen.1. Hydrazine was oxidized readily by flavinium cation-ratalyzed aerobic oxidation to give diazene, which is a highly active hydrogen donor towards unsaturated bonds. Using the system, the author developed environmentally f iendly hydrogenation method for olefins without using metal catalysts and hydrogen gas.3. Dendrimers bearing diaminopyridine core bind flavin molecules through three-point hydrogen bonding interaction to form flavin-dendrimer complexes. The compexes exhibited high catalytic performance due to the hydrohobic environment around the catalyst.3. Dendrimers bearing diaminopyridine core bind flavin molecules through three-point hydrogen bonding interaction to fomi flavin-dendrimer complexes. The compexes exhibited high catalytic performance due to the hydrohobic environment around the catalyst.4. Gold nanoparticles can be functionalized by flavin molecules. The flavin-functionalized gold nanoparticles can be used as catalysts for aerobic oxidation of sulfides and aerobic hydrogenation of of efins.