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Molecular and pathogenic mechanisms for peripheral neuropathy associated with metabolic syndrome

代谢综合征相关周围神经病的分子和致病机制

基本信息

批准号：
18590520
负责人：
SUGIMOTO Kazuhiro
金额：
$ 1.49万
依托单位：
Hirosaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

Small sensory fiber dysfunction has recently been recognized as a component of impaired glucose tolerance and metabolic syndrome. However, few studies have investigated whether small sensory fiber dysfunction develops in normoglycemic or prediabetic animal models with metabolic syndrome. Longitudinal trends for thermal and mechanical nociceptive responses were assessed in 8-to 36-week-old male obese Zucker rats, 8-to 36-week-old male Zucker diabetic fatty (ZDF) rats. Data were compared with metabolic disorders in these rats. Both obese Zucker and ZDF rats at 8 weeks of age showed compensatory hyperinsulinemia and developed thermal hyperalgesia prior to the onset of overt hyperglycemia. These animals also exhibited progression from thermal hyperalgesia to hyperalgesia, which occurred more rapidly and coincided with a more rapid decline in pancreatic insulin secretion in ZDF rats than in obese Zucker rats. Based on these findings we conclude that metabolic syndrome with or without compensatory hyperinsulinemia is associated with nociceptive dysfunction having different phenotypes, independently of glycemic levels.

小感觉纤维功能障碍最近被认为是糖耐量受损和代谢综合征的一个组成部分。然而，很少有研究调查是否小的感觉纤维功能障碍发展在血糖正常或糖尿病前期动物模型代谢综合征。在8- 36周龄雄性肥胖Zucker大鼠和8- 36周龄雄性糖尿病Zucker脂肪（ZDF）大鼠中评估了热和机械伤害性反应的纵向趋势。将这些大鼠的数据与代谢紊乱进行比较。肥胖Zucker和ZDF大鼠在8周龄时表现出代偿性高胰岛素血症，并在明显的高血糖症发作之前出现热痛觉过敏。这些动物还表现出从热痛觉过敏到痛觉过敏的进展，这发生得更快，并且与ZDF大鼠中胰腺胰岛素分泌比肥胖Zucker大鼠中更快的下降相一致。基于这些发现，我们得出结论，代谢综合征伴或不伴代偿性高胰岛素血症与伤害性功能障碍相关，具有不同的表型，独立于血糖水平。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A Novel Mutation in the Arylsulfatase A Gene Associated with Adult-Onset Metachromatic Leukodystrophy without Clinical Evidence of Neuropathy

芳基硫酸酯酶 A 基因的新突变与成人发病的异染性脑白质营养不良相关，但没有神经病的临床证据

DOI：
发表时间：
2008
期刊：
Eur Neurol 60
影响因子：
0
作者：
Suzuki C;Watanabe M;Tomiyama M,Sugimoto K;Nanba E;Jackson M;KimuraT;Seino Y;Wakasaya Y;KawarabayashiT;Miki Y;Yamamoto-Watanabe Y;Shoji M
通讯作者：
Shoji M

肥満Zuckerおよび2型糖尿病ZDFラットモデルの温痛覚の経時変化

肥胖Zucker和2型糖尿病ZDF大鼠模型热痛觉时程