The development of the image database for cancer-related protein /gene interaction pathway

我们开发了癌症相关蛋白相互作用途径的图像集成数据库系统Cancer Pro View。对于这个数据库，我们实现了以下数据内容和分析功能：(1)癌症相关蛋白、功能域、相互作用途径和相关疾病的图像显示(2)癌症相关基因突变和遗传多态性的图形视图(3)具有共同功能域的适当癌症相关蛋白的搜索能力(4)从基因符号中找到相应的癌症相关基因和蛋白质(5)使用蛋白质功能域名称搜索适当的蛋白质(6)日语或英语关键词搜索。在本CancerProView中，我们收集了84个疾病基因的数据，包括45个癌症相关基因（BRCA1、BRCA2、AKT2、CSF1R、ELK1等），22个蛋白质相互作用通路图，111篇文献，355个cDNA核苷酸序列和蛋白质氨基酸序列。这些数据内容来自不同的数据库（蛋白质结构域的SMART，疾病基因的HGMD和OMIM， cDNA序列的Refseq和文献的PubMed）。CancerProView数据库使用Web浏览器操作，其原型系统可在主页（http://131.113.190.16/php/crpd.html）上找到。CancerProView将成为通过癌症相关蛋白及其相互作用途径更好地了解癌症发病机制的有用工具。它对于发展分子诊断和药物发现也是不可缺少的。

We have developed an image integrated database system Cancer Pro View for interaction pathways of cancer-related proteins. For this database, we implemented the following data contents and analytical functions: (1) image display of cancer-related proteins, functional domains, interaction pathways and associated diseases (2) graphical view of cancer-related gene mutations and genetic polymorphisms (3) search capability of appropriate cancer-related proteins that have common functional domains (4) finding of corresponding cancer-related genes and proteins from gene symbol (5) search for proper proteins using name of protein functional domain (6) keyword search with either Japanese or English. In this CancerProView, we collected data on 84 disease genes including 45 cancer-related genes (BRCA1, BRCA2, AKT2, CSF1R, ELK1 etc.), 22 pathway charts for protein interaction, 111 literatures, 355 cDNA nucleotide sequences and protein amino acid sequences. These data contents were adapted from various databases (SMART for protein domains, HGMD and OMIM for disease genes, Refseq for cDNA sequences and PubMed for literatures). The CancerProView database is operated using a Web browser and a prototype system is available at homepage (http://131.113.190.16/php/crpd.html). The CancerProView will serve as a useful tool for better understanding the cancer pathogenesis through cancer-related proteins and their interaction pathways. It is also invariable for developing molecular diagnosis and drug discovery.