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The development of the image database for cancer-related protein /gene interaction pathway

癌症相关蛋白/基因相互作用通路图像数据库的开发

基本信息

批准号：
18590538
负责人：
MITSUYAMA Susumu
金额：
$ 2.57万
依托单位：
Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590538/
关键词：
Cancer Database Protein Gene Pathway Image Disease Functional domain

项目摘要

We have developed an image integrated database system Cancer Pro View for interaction pathways of cancer-related proteins. For this database, we implemented the following data contents and analytical functions: (1) image display of cancer-related proteins, functional domains, interaction pathways and associated diseases (2) graphical view of cancer-related gene mutations and genetic polymorphisms (3) search capability of appropriate cancer-related proteins that have common functional domains (4) finding of corresponding cancer-related genes and proteins from gene symbol (5) search for proper proteins using name of protein functional domain (6) keyword search with either Japanese or English. In this CancerProView, we collected data on 84 disease genes including 45 cancer-related genes (BRCA1, BRCA2, AKT2, CSF1R, ELK1 etc.), 22 pathway charts for protein interaction, 111 literatures, 355 cDNA nucleotide sequences and protein amino acid sequences. These data contents were adapted from various databases (SMART for protein domains, HGMD and OMIM for disease genes, Refseq for cDNA sequences and PubMed for literatures). The CancerProView database is operated using a Web browser and a prototype system is available at homepage (http://131.113.190.16/php/crpd.html). The CancerProView will serve as a useful tool for better understanding the cancer pathogenesis through cancer-related proteins and their interaction pathways. It is also invariable for developing molecular diagnosis and drug discovery.

我们开发了一个图像集成数据库系统 Cancer Pro View，用于研究癌症相关蛋白质的相互作用途径。对于该数据库，我们实现了以下数据内容和分析功能：（1）癌症相关蛋白、功能域、相互作用途径和相关疾病的图像显示（2）癌症相关基因突变和遗传多态性的图形视图（3）具有共同功能域的适当癌症相关蛋白的搜索能力（4）从基因符号中查找相应的癌症相关基因和蛋白质（5）使用蛋白质功能域名称搜索适当的蛋白质 (6) 使用日语或英语进行关键字搜索。在这个CancerProView中，我们收集了84个疾病基因的数据，包括45个癌症相关基因（BRCA1、BRCA2、AKT2、CSF1R、ELK1等）、22个蛋白质相互作用通路图、111篇文献、355个cDNA核苷酸序列和蛋白质氨基酸序列。这些数据内容改编自各种数据库（用于蛋白质结构域的 SMART、用于疾病基因的 HGMD 和 OMIM、用于 cDNA 序列的 Refseq 以及用于文献的 PubMed）。 CancerProView数据库使用Web浏览器进行操作，原型系统可在主页（http://131.113.190.16/php/crpd.html）上找到。 CancerProView 将作为一个有用的工具，通过癌症相关蛋白及其相互作用途径更好地了解癌症发病机制。对于分子诊断和药物发现的发展也是不变的。