The Role of Side Population Cell in Skeletal Muscle on post infarcted LV remodeling

骨骼肌侧群细胞在梗死后左室重塑中的作用

• 批准号: 18590785
• 负责人: YOSHIYAMA Minoru
• 金额: $ 2.49万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590785/
• 关键词: Side Population Cell; Transplantation; Regenerative Medicin

Despite the advance in pharmacotherapeutics and mechanical interventions, the cardiomyocytes lost during myocardial infarction (MI) cannot be regenerated. Consequently, the loss of cardiomyocytes in MI is a major cause of heart failure. As a potential method, cell transplantation to myocardium has been studied for a decade. Side Population Cell in Skeletal Muscle transplantation could be potential therapy for heart damage in experimentally. However, the safety, efficacy of their transplantation are controversial. In this study, we investigate that whether Side Population' Cell in Skeletal Muscle can be a good cell source. In the present study, we transplanted Side Population Cell in Skeletal Muscle into infracted mouse hearts and investigate that (1) whether engrafted Side Population Cell in Skeletal Muscle improve post infarcted cardiac function, (2) whether Side Population Cell in Skeletal Muscle myoblasts can transdifferentiate into cardiomyocytes in vitro and in vivo.

尽管在药物治疗和机械干预方面取得了进展，但心肌梗死（MI）期间丢失的心肌细胞无法再生。因此，心肌细胞的损失是心衰的主要原因。作为一种潜在的方法，细胞移植到心肌的研究已经进行了十年。骨骼肌侧群细胞移植是一种潜在的心脏损伤治疗方法。然而，移植的安全性和有效性存在争议。在本研究中，我们探讨了骨骼肌侧群细胞是否可以作为一个良好的细胞来源。在本研究中，我们将骨骼肌侧群细胞移植到梗死小鼠心脏中，研究(1)移植的骨骼肌侧群细胞是否能改善梗死后的心功能，(2)骨骼肌侧群细胞是否能在体外和体内转分化为心肌细胞。

项目成果

Quantification of coronary calcification by intravascular ultrasound.

通过血管内超声量化冠状动脉钙化。

• 发表时间: 2007
• 期刊: Circ J 71
• 作者: Ehara S;Ueda M;et. al.
• 通讯作者: et. al.

Assessment of Daily Fluctuations in 12-Lead Electrocardiogram and Signal Averaged Electrocardiogram at Risk for Life-threatening Arrhythmic Eventsin Brugada Syndrome

评估布鲁格达综合征中危及生命的心律失常事件风险的 12 导联心电图和信号平均心电图的每日波动

• 发表时间: 2007
• 作者: Atsushi Doi;Masahiko Takagi;Keiko Maeda;Hiroaki Tatsumi;Eiichiro Nakagawa;Hajime Yamashita;Minoru Yoshiyama
• 通讯作者: Minoru Yoshiyama

Assessment of Daily Fluctuations in 12-Lead Electrocardiogram and Signal Averaged Electrocardiogram at Risk for Life-threatening Arrhythmic EventS in Brugada Syndrome

布鲁格达综合征危及生命的心律失常事件风险中 12 导联心电图和信号平均心电图每日波动的评估

• 发表时间: 2007
• 作者: Atsushi Doi;Masahiko Takagi;Keiko Maeda;Hiroaki Tatsumi;Eiichiro Nakagaw4 Hajime Yamashita;Minoru Yoshiyama
• 通讯作者: Minoru Yoshiyama

Functional mitral regurgitation predicts prognosis independent of left ventricular systolic and diastolic indices in patients with ischemic heart disease.

• DOI: 10.1016/j.echo.2007.06.002
• 发表时间: 2008-04
• 期刊: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
• 作者: H. Okura;Y. Takada;T. Kubo;K. Asawa;H. Taguchi;I. Toda;M. Yoshiyama;J. Yoshikawa;Kiyoshi Yoshida-Kiyoshi-Yosh

Relation of early improvement in coronary flow reserve to late recovery of left ventricular function after beba-blocker therapy in patients with idiopathic dilated cardiomyopathy

特发性扩张型心肌病患者贝巴阻滞剂治疗后冠状动脉血流储备早期改善与左心室功能晚期恢复的关系

• 发表时间: 2007
• 期刊: Am Heart J. 153(6)
• 作者: Sugioka K;Hozumi T;Takemoto Y;Ehara S;Ogawa K;Iwata S;Oe H;Matsumura Y;Otsuka R;Yoshiyama M;Yoshikawa J
• 通讯作者: Yoshikawa J