Analysis of cytotoxic effect of human Granulysin by using novel PK/PD model

利用新型 PK/PD 模型分析人颗粒溶素的细胞毒作用

• 批准号: 18590875
• 负责人: KUBO Akihito
• 金额: $ 2.62万
• 依托单位: Clinical Research Center, National Hospital Organization, Kinki-Chuo Chest Medical Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590875/
• 关键词: 肺癌; 免疫療法; 癌; 免疫学; グラニュライシン; 応用動物

無差別的な細胞傷害性を示さない分子標的薬剤を用いて癌性胸膜炎で胸に細胞浸出液が貯留した肺癌患者を行い、その際に廃棄される胸水を用いることで細胞障害性キラーT細胞が分泌する細胞障害因子グラニュライシン(Gra)を測定し治療反応性との相関を検討した。

The use of molecular markers for the determination of cytotoxic factors secreted by T cells in carcinomatous pleurisy, chest cell extracts stored in lung cancer patients, and pleural effusions discarded at the time of treatment, and the correlation between therapeutic response and therapeutic response were discussed.

项目成果

Compensation of type I and type II cytokeratin pools in lung cancer

• DOI: 10.1016/j.lungcan.2006.11.004
• 发表时间: 2007-03-01
• 期刊: LUNG CANCER
• 影响因子: 5.3
• 作者: Kanaji, Nobuhiro;Bandoh, Shuji;Kubo, Akihito
• 通讯作者: Kubo, Akihito

Compensation of type I and II cytokeratin pools in lung cancer.

肺癌中 I 型和 II 型细胞角蛋白库的补偿。

• 发表时间: 2007
• 期刊: Lung Cancer 55
• 作者: Kanaji;N.
• 通讯作者: N.

EGFR R497K polymorphism is a favorable prognostic factor for advanced lung cancer

• DOI: 10.1007/s00432-008-0464-5
• 发表时间: 2009-02-01
• 期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
• 影响因子: 3.6
• 作者: Sasaki, Hidefumi;Okuda, Katsuhiro;Fujii, Yoshitaka
• 通讯作者: Fujii, Yoshitaka

Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification

• DOI: 10.1158/0008-5472.can-06-3339
• 发表时间: 2007-03-01
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Okabe, Takafumi;Okamoto, Isamu;Nakagawa, Kazuhiko
• 通讯作者: Nakagawa, Kazuhiko

Full-length cytokeratin 8 is released and circulates in patients with non-small cell lung cancer

• DOI: 10.1159/000132572
• 发表时间: 2008-01-01
• 期刊: TUMOR BIOLOGY
• 作者: Ishii, Tomoya;Bandoh, Shuji;Kubo, Akihito
• 通讯作者: Kubo, Akihito