The study of amino acid neurotransmitter changes in mood disorder and anxiety disorder assessed by high field proton MRS.

通过高场质子 MRS 评估情绪障碍和焦虑障碍中氨基酸神经递质变化的研究。

• 批准号: 18591291
• 负责人: SUMITANI Satsuki
• 金额: $ 2.49万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591291/
• 关键词: glutamate; GABA; MRS; mood disorder; anxiety disorder; OCD

To investigate the abnormalities of neural function or metabolism in mental disorders, we measured the neurochemical changes in the anterior cingulate (ACC) and bilateral basal ganglia by using high magnetic field (3 Tesla) proton magnetic resonance spectroscopy (MRS) in the patients of mood disorders and anxiety disorders. Especially, we examined changes of the level of amino acid neurotransmitter such as glutamate and gamma amino butyric acid (GABA).Obsessive-compulsive disorder (OCD) patients had significantly reduced levels of N-acetyl aspertate (NAA) and glutamate (Glu) in the ACC compared to matched controls. NAA levels in the right basal ganglia in OCD patients were higher than those in the left basal ganglia. No differences were found in levels of GABA between OCD patients and controls. Panic disorder patients had significantly higher levels of Glx (glutamate+glutamine) in the right basal ganglia compared to controls. Major depression patients had significantly reduced levels of Glu in the ACC compared to controls.In the present study we found specific changes of amino acid neurotransmitters in each disorder, although these findings are preliminary that need further study with more samples.

为了探讨精神障碍患者的神经功能或代谢异常，我们用强磁场(3特斯拉)质子磁共振波谱(MRS)检测了心境障碍和焦虑症患者扣带前核(ACC)和双侧基底节的神经化学变化。强迫症(OCD)患者血清N-乙酰天冬氨酸(NAA)和谷氨酸(Glu)水平明显低于对照组。强迫症患者右侧基底节NAA水平高于左侧基底节。强迫症患者和对照组之间的GABA水平没有发现差异。惊恐障碍患者右侧基底节GLX(谷氨酸+谷氨酰胺)水平显著高于对照组。与对照组相比，重度抑郁症患者ACC中的谷氨酸水平显著降低。在本研究中，我们发现在每种疾病中氨基酸神经递质的具体变化，尽管这些发现是初步的，需要更多的样本进行进一步研究。

项目成果

3T proton MRSを用いたOCDの脳内代謝物の検討

使用 3T 质子 MRS 检查强迫症患者的脑代谢物

• 发表时间: 2006
• 作者: 佐竹隆宏、兼子幸一;ら;住谷さっき
• 通讯作者: 住谷さっき

A practical guide for the treatment of OCD Neuroscience of OCD

强迫症治疗实用指南 强迫症神经科学

• 发表时间: 2006
• 期刊: Kongo Shuppan
• 作者: Yuki Kako;Nobuki Kitagawa;Kenzo Denda;Tsukasa Koyama;Satsuki Sumitani;傳田健三;Sumiko Shibuya-Tayoshi S;Satsuki Sumitani;Kenzo Denda;Sumiko Shibuya-Tayoshi;傳田健三;S. Shibuya-Tayoshi,;Kenzo Denda;H. Song,;傳田健三;H. Aki,;Kenzo Denda;傳田健三;S. Numata,;Kenzo Denda;住谷 さつき;傳田健三;傳田健三(鍋田恭孝編);Satsuki Sumitani
• 通讯作者: Satsuki Sumitani

快・不快の情動ストレスに対する前頭葉血流変化の評価-多チャンネルNIRSを用いた検討-

评估额叶血流变化对愉快和不愉快情绪压力的反应 - 使用多通道 NIRS 进行研究 -

• 发表时间: 2007
• 作者: 佐竹隆宏;兼子幸一;宮田 幸奈
• 通讯作者: 宮田 幸奈

Lithiun effects on brain glutamatergic and GABAergic systems of healthy volunteers as measured by proton resonance spectroscopy

通过质子共振光谱测量锂对健康志愿者大脑谷氨酸能和 GABA 能系统的影响

• 发表时间: 2008
• 期刊: Progress in Neuro-Psychopharmacology and Bological Psychiatry 32
• 作者: Hitoshi Saino;Takehiko Kawai;Shinji Kurokawa;Kenzo Denda;S. Shibuya-Tayoshi,
• 通讯作者: S. Shibuya-Tayoshi,

表情認知における前頭葉血流変化と自閉症スペクトラム指数(AQ)との関連-多チャンネルNIRSを用いた検討-

面部表情识别中额叶血流变化与自闭症谱商（AQ）之间的关系 - 使用多通道 NIRS 的研究 -

• 发表时间: 2007
• 作者: Satake;T.;Mitani;H.;Nakagome;K.;Kaneko;K;秋山 麻衣
• 通讯作者: 秋山 麻衣