A study of treatment strategies for obsessive-compulsive disorder by using cognitive performance and functional neuroimagings

利用认知表现和功能神经影像学研究强迫症的治疗策略

• 批准号: 23591709
• 负责人: SUMITANI Satsuki
• 金额: $ 3.33万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591709/
• 关键词: 強迫性障害; 認知機能; 機能画像; 前頭葉; 基底核; NIRS; MRS; 前頭葉機能; GABA; 脳血流; Stroop Test; グルタミン酸

We studied to find strategies for obsessive compulsive disorder(OCD) by using cognitive performance and functional neuroimagings. We found abnormalities of metabolites of right basal ganglia of OCD patients by using 3 tesla proton magnetic resonance spectroscopy (MRS). Moreover we found a significantly lower cognitive performance and a hypofrontality of OCD patients by using multichannel NIRS compared to control group. It is suggested that we might choose strategies for OCD patients who have different biological feature individually.

我们研究通过使用认知表现和功能神经成像来寻找治疗强迫症(OCD)的策略。应用3特斯拉质子磁共振波谱(MRS)发现强迫症患者右侧基底节代谢产物异常。此外，我们还发现，与对照组相比，多通道近红外光谱显示强迫症患者的认知能力显着降低，额叶减少。提示对不同生物学特征的强迫症患者可选择不同的治疗策略。

项目成果

Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia.

• DOI: 10.1093/schbul/sbt154
• 发表时间: 2014-09
• 期刊: Schizophrenia bulletin
• 影响因子: 6.6
• 作者: Nishi A;Numata S;Tajima A;Kinoshita M;Kikuchi K;Shimodera S;Tomotake M;Ohi K;Hashimoto R;Imoto I;Takeda M;Ohmori T
• 通讯作者: Ohmori T

Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument

• DOI: 10.1007/s10803-010-1065-0
• 发表时间: 2011-04-01
• 期刊: JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
• 影响因子: 3.9
• 作者: Harada, Masafumi;Taki, Masako M.;Matsuda, Tsuyoshi
• 通讯作者: Matsuda, Tsuyoshi

Quality of life and its predictors in people with schizophrenia

精神分裂症患者的生活质量及其预测因素

• 发表时间: 2012
• 期刊: J Med Invest
• 作者: Hashimoto M. Sakamoto S;Ikeda M.;Tomotake M
• 通讯作者: Tomotake M

Factors Associated with Discharge of Long-Term Inpatients with Schizophrenia in Japan: A Retrospective Study

• DOI: 10.3109/01612840.2012.742602
• 发表时间: 2013-04-01
• 期刊: ISSUES IN MENTAL HEALTH NURSING
• 影响因子: 2.1
• 作者: Tanioka, Tetsuya;Chiba, Shinichi;Mifune, Kazushi
• 通讯作者: Mifune, Kazushi

Preliminary Observation of Dynamic Changes in Alcohol Concentration in the Human Brain with Proton Magnetic Resonance Spectroscopy on a 3T MR Instrument

• DOI: 10.2463/mrms.2012-0056
• 发表时间: 2013-01-01
• 期刊: MAGNETIC RESONANCE IN MEDICAL SCIENCES
• 影响因子: 3
• 作者: Kubo, Hitoshi;Harada, Masafumi;Otsuka, Hideki
• 通讯作者: Otsuka, Hideki