Comprehensive assessment of coronary artery disease by using coronary MRA and quantitative analysis of myocardial perfusion MRI

冠状动脉MRA综合评估冠心病及心肌灌注MRI定量分析

• 批准号: 18591340
• 负责人: HAJIME Sakuma
• 金额: $ 2.48万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591340/
• 关键词: MRI; 冠動脈疾患; 心筋血流; 冠動脈MRA; 狭心症; 心筋梗塞; 冠動脈; 動脈硬化プラーク; 冠動脈MRアンギオギラフィ; ガドリニウム造影剤; 心筋パーフュージョンMRI

冠動脈MRAと心筋パーフュージョンMRI定量解析による冠動脈疾患の総合的評価を行った。MRIによる心筋血流量(ml/min/g)はアンモニア心筋血流PET による結果とよく一致し、負荷心筋パーフュージョンMRI の有意冠動脈狭窄診断感度は89%、特異度は91%であった。冠動脈MRA は放射線被曝を伴わない非侵襲的な冠動脈評価を可能とし、その診断感度は92%、特異度は90%と高かった。冠動脈MRAと心筋パーフュージョンMRI を実施することは、冠動脈病変の鋭敏な検出と、虚血の有無に基づく的確な冠動脈インターベンションの適応決定に役立つ。

Coronary artery MRA and MRI quantitative analysis of coronary artery disease MRI cardiac blood flow (ml/min/g) was consistent with PET results. The sensitivity and specificity of MRI for diagnosis of intentional coronary artery stenosis were 89% and 91% respectively. Coronary artery MRA was associated with radiation exposure and non-invasive coronary artery evaluation. The diagnostic sensitivity was 92%, and the specificity was 90%. Coronary artery MRA and cardiac MRI are performed in response to acute coronary disease detection, presence or absence of blood deficiency, and determination of coronary artery disease response.

项目成果

Absolute quantification of myocardial blood flow from rest perfusion MRI can provide improved sensitivity for predicting myocardial viability in patients early after myocardial infarction

静息灌注 MRI 中心肌血流量的绝对定量可以提高预测心肌梗死后早期患者心肌活力的灵敏度

• 发表时间: 2008
• 作者: Nagata M;Sakuma H;Kurita T;Ishida N;Ishida M;Mikami Y;Nakajima H;Ito M;Takeda K.
• 通讯作者: Takeda K.

Comparison between Radio-water PET and Model Based Quantitative Analysis of Myocardial Perfusion Magnetic Resonance

无线电水 PET 与基于模型的心肌灌注磁共振定量分析的比较

• 发表时间: 2007
• 作者: Ishida M;Parkka JP;Sakuma H;Nagata M;Ishida N;Mikami Y;Ichihara T;Takeda K;Maeda H;Goko Y;Kunuuti J;Hartiala JJ
• 通讯作者: Hartiala JJ

Diagnostic accuracy of stress myocardial perfusion MRI and late gadolinium-enhanced MRI for detecting flow-limiting coronary artery disease: a multicenter study

• DOI: 10.1007/s00330-008-1097-4
• 发表时间: 2008-12-01
• 期刊: EUROPEAN RADIOLOGY
• 影响因子: 5.9
• 作者: Kitagawa, Kakuya;Sakuma, Hajime;Takeda, Kan
• 通讯作者: Takeda, Kan

Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging

• DOI: 10.1253/circj.72.378
• 发表时间: 2008-03-01
• 期刊: CIRCULATION JOURNAL
• 影响因子: 3.3
• 作者: Motoyasu, Munenobu;Kurita, Tairo;Sakuma, Hajime
• 通讯作者: Sakuma, Hajime

Myocardial Perfusion Reserve Determined by Model Based Quantitative Analysis of Stress-Rest Perfusion MRI Permits Improved Accuracy in Predicting Coronary Artery Diseases When Compared with Semiquantitative Analysis

与半定量分析相比，通过基于模型的应激-静息灌注 MRI 定量分析确定心肌灌注储备，可以提高预测冠状动脉疾病的准确性

• 发表时间: 2007
• 作者: Ishida M;Sakuma H;Shi Y;Nagata M;Ishida N;Mikami Y;Ichihara T;Maeda H;Goko Y;Kurita T;Ito M;Takeda K
• 通讯作者: Takeda K