Development of environment-conscious synthetic reactions : construction of reaction coordinate-response catalyst

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Environment and resource conservation is the most urgent issue that human beings face. To address this issue and construct a sustainable society, development of selective, atom-efficient and eco-friendly synthetic reactions is essential. Biological material transformation systems are highly selective and atom-efficient and green, but several enzymes participate in most biological systems that are difficult to be implemented by the current chemical way. To realize equally green and efficient reactions with a catalyst, we designed complexes that can change their structure and exhibit an appropriate catalytic performance along reaction coordinate. With such complexes as catalyst, we could successfully achieve highly enantioselective and atom-efficient oxidation reactions using molecular oxygen or hydrogen peroxide as the terminal oxidant. This research demonstrated the effectiveness of a catalyst that can change its catalytic performance along reaction coordinate, for realizing a green reaction.