Development of environment-conscious synthetic reactions : construction of reaction coordinate-response catalyst

环境意识合成反应的发展：反应配位响应催化剂的构建

• 批准号: 18002011
• 负责人: KATSUKI Tsutomu
• 金额: $ 212.24万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Specially Promoted Research
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18002011/
• 关键词: 環境調和; 多重機能触媒; 過酸化水素水; 分子状酸素; 水素結合; エポキシ化; 光分子デバイス; 水素生成触媒; 光活性化; 還境調和

Environment and resource conservation is the most urgent issue that human beings face. To address this issue and construct a sustainable society, development of selective, atom-efficient and eco-friendly synthetic reactions is essential. Biological material transformation systems are highly selective and atom-efficient and green, but several enzymes participate in most biological systems that are difficult to be implemented by the current chemical way. To realize equally green and efficient reactions with a catalyst, we designed complexes that can change their structure and exhibit an appropriate catalytic performance along reaction coordinate. With such complexes as catalyst, we could successfully achieve highly enantioselective and atom-efficient oxidation reactions using molecular oxygen or hydrogen peroxide as the terminal oxidant. This research demonstrated the effectiveness of a catalyst that can change its catalytic performance along reaction coordinate, for realizing a green reaction.

节约环境和资源是人类面临的最紧迫的问题。为了解决这一问题，构建一个可持续发展的社会，开发选择性、原子效率高和环境友好的合成反应是必不可少的。生物材料转化系统具有高选择性、原子效率高、绿色环保等优点，但目前大多数生物材料转化系统中都有几种酶参与，而目前的化学方法很难实现。为了在催化剂的作用下实现同样绿色高效的反应，我们设计了可以改变其结构并沿反应坐标表现出适当催化性能的络合物。以这种配合物为催化剂，以分子氧或过氧化氢为末端氧化剂，可成功地实现高对映选择性和原子效率高的氧化反应。本研究证明了一种催化剂可以沿反应坐标改变其催化性能，从而实现绿色反应的有效性。

项目成果

Titanium-catalyzed asymmetric epoxidation of non-activated olefins with hydrogen peroxide.

• DOI: 10.1002/anie.200700949
• 发表时间: 2007-06
• 期刊: Angewandte Chemie
• 作者: Y. Sawada;Kazuhiro Matsumoto;T. Katsuki*

Highly Enantioselective Epoxidation of Styrenes Catalyzed by Proline-Derived C1-Symmetric Titanium(Salan) Complexes

• DOI: 10.1002/anie.200903567
• 发表时间: 2009-01-01
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Matsumoto, Kazuhiro;Oguma, Takuya;Katsuki, Tsutomu
• 通讯作者: Katsuki, Tsutomu

イリジウムサレン錯体を触媒とする不斉C-Hカルベン挿入反応の研究

铱salen配合物催化不对称C-H卡宾插入反应的研究

• 发表时间: 2009
• 作者: 末松英浩;香月勗
• 通讯作者: 香月勗

Evidence for Pt(II)-Based Molecular Catalysis in the Thermal Reduction of Water into Molecular Hydrogen

Pt(II) 基分子催化水热还原成分子氢的证据

• 发表时间: 2009
• 期刊: J. Am. Chem. Soc
• 作者: Kosei Yamauchi;Shigeyuki Masaoka;and Ken Sakai
• 通讯作者: and Ken Sakai

フェニルピリジナトを有するルテニウム単核錯体の合成と酸素発生触媒機能

苯基吡啶钌单核配合物的合成及其析氧催化功能

• 发表时间: 2009
• 作者: Takehito DEI;Kazuhide MORINO;Atsushi SUDO;and Takeshi ENDO;乾智也;H. Watanabe;木本彩乃・正岡重行・酒井健
• 通讯作者: 木本彩乃・正岡重行・酒井健