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Dynamic Stereocontrol

动态立体控制

基本信息

批准号：
10208104
负责人：
KATSUKI Tsutomu
金额：
$ 55.04万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas (B)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

Research Project "Dynamic Stereocontrol" has been successfully carried out for three years from 1998 to 2000 and rewarded with acquisition of new concepts for dynamic stereocontrol and invention of new methodologies for stereocontrol of organic reactions, generation of active species such as radical and carbene, and chiral separation. Representative achievements of the project are i) stereocontrol of reactions of carbonyl compounds by using a conceptually new chiral bidentate Lewis acid catalyst, ii) Construction of asymmetric reaction site by dynamic control of the conformation of achiral catalyst, iii) exploration of new type of asymmetric catalyst activated by photo-irradiation, iv) enhancement of asymmetry inducing ability of chiral catalyst by synergistic influence of achiral ligand, v) exploitation of radical reaction in aqueous medium, vi) stereocontrol of carbocation species and introduction of new methodology for construction of cyclic compounds, vii) sequential generation of … More carbon radicals and carbanions : dynamic stereocontrol in the reaction sequence, viii) construction of chiral stationary phases (CSPs) for thin layer chromatography (TLC), ix) development of molecular machine, a light-powered chiral molecular motor.In the present reasearch, the achievements obtained in the project were collected and evaluated by the research members including many distinguished chemists in our country. Furthermore, the results of the project were thouroughly discussed through the opened symposium. Based on the analysis of the results by these discussions and evaluation, the achievements were recognized to have greatly contributed to advancement of organic synthesis and chiral separation, especially to development of stereocontrol and molecular recognition.From the analysis, the necessity of continuing promotion of dynamic stereocontrol which will lay a foundation for ecologically acceptable, atom-efficient and high-yielding synthetic chemistry and for production of completely optically pure materials was also recognized.Report of the present research will be published as the research report entitled "Reseach on Dynamic Stereocontrol." Less

1998年至2000年成功开展了三年的“动态立体控制”研究项目，获得了动态立体控制的新概念，发明了有机反应的立体控制、自由基和卡宾等活性物种的产生以及手性分离的新方法。本项目的代表性成果是：i）利用一种新的手性双齿刘易斯酸催化剂对羰基化合物的反应进行立体控制，ii）通过动态控制非手性催化剂的构象来构建不对称反应位点，iii）探索新型的光辐射活化的不对称催化剂，iv）通过非手性配体的协同影响来增强手性催化剂的不对称诱导能力，v）利用水介质中的自由基反应，vi）碳阳离子物种的立体控制和引入构建环状化合物的新方法，vii）连续生成 ...更多信息本文收集了我国化学家在这一课题中的研究成果，并对这些成果进行了评价。此外，通过公开的专题讨论会深入讨论了该项目的结果。通过对这些讨论和评价结果的分析，认为这些成果对有机合成和手性分离的发展，特别是对立体控制和分子识别的发展作出了巨大贡献，并指出了继续推进动态立体控制的必要性，为生态可接受的、本研究报告将作为题为“动态立体控制研究”的研究报告发表。“减