Structures and Functions of Membrane-Bound Biomolecules
Structures and Functions of Membrane-Bound Biomolecules
批准号:
18101010
负责人:
MURATA Michio
金额:
$70.8万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2010
中文摘要
生物膜被认为是一种难以捉摸的液体介质,是生命所必需的实体。在这个项目中,我们研究了负责生物功能的膜脂的三维结构。同位素标记分子的固体核磁共振测量使我们能够阐明双层膜中抗生素和磷脂的结构和动力学。
英文摘要
Biomembrane, essential entity for life, has been regarded as an elusive liquid medium. In this project, we have examined the 3D structures of membrane lipids which are responsible for biological functions. Solid-state NMR measurements for isotope-labeled molecules allowed us to elucidate the structures and dynamics of antibiotics and phospholipids residing in bilayer membranes.
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effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.
表面等离振子共振证明了对amphidinol 3和脂质体膜之间相互作用的影响。
DOI:
--
发表时间:
2010
期刊:
Bioorg.Med.Chem.Lett. 20
影响因子:
--
作者:
[Swasono, R., Mouri, R., Morsy, N., Matsumori, N., Oishi, T., Murata, M.Sterol]
通讯作者:
M.Sterol
Valosin-containing protein (VCP)/p97 interacts with SAAF in the ascidian egg and modulates sperm-attracting activity.
含 Valosin 的蛋白 (VCP)/p97 与海鞘卵中的 SAAF 相互作用并调节精子吸引活性。
DOI:
--
发表时间:
2008
期刊:
Develop. Grow. Differ. 50
影响因子:
--
作者:
[Kondoh, E., Konno, A., Inaba, K., Oishi, T., Murata, M., Yoshida, M.]
通讯作者:
M.
Interaction of ladder-shaped polyethers with transmembrane α-helix of glycophorin A as evidenced by saturation transfer difference NMR and surface plasmon resonace.
梯形聚醚与血型糖蛋白 A 跨膜 α-螺旋的相互作用,通过饱和转移差 NMR 和表面等离子共振得到证实。
DOI:
--
发表时间:
2008
期刊:
Bioorg.Med.Chem.Lett. 18
影响因子:
--
作者:
[Ujihara, S., Oishi, T., Torikai, K., Konoki, K., Matsumori, N., Murata, M., Oshima, Y., Aimoto, S.]
通讯作者:
S.
Sterol Effect on Interaction between Amphidinol 3 and Liposomal Membrane as Evidenced by Surface Plasmon Resonance
表面等离子共振证明甾醇对 Amphidinol 3 与脂质体膜相互作用的影响
DOI:
--
发表时间:
2010
期刊:
Tohru Oishi, Michio Murata B i oo rg. Med. Chem. L ett
影响因子:
--
作者:
[Respati Swasono, Ryota Mouri, Nagy Morsy, Nobuaki Matsumori]
通讯作者:
Nobuaki Matsumori
Amphotericin B-induced ion flux is markedly attenuated in phosphatidylglycerol membrane as evidenced by a newly devised fluorometric method.
新设计的荧光方法证明,两性霉素 B 诱导的离子通量在磷脂酰甘油膜中显着减弱。
DOI:
--
发表时间:
2009
期刊:
Bioorg.Med.Chem. 17
影响因子:
--
作者:
[T. Takano, K. Konoki, N. Matsumori, M. Murata]
通讯作者:
M. Murata
共 50 条
Dynamic conformation and domain structure of lipid molecules in model biomembranes
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批准号:16H06315
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财政年份:2016
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财政年份:2003
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Frontier in Structure Elucidation of Natural Products
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批准号:12045243
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财政年份:2000
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Practical Configuration Analysis for Natural Products.
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批准号:10554043
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财政年份:1998
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负责人:MURATA Michio
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Molecular Mechanism of Action for Particularly Potent Marine Biotoxins.
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Membrane Protein Recognition by Ladder-shaped Polyether Compounds
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财政年份:1996
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负责人:MURATA Michio
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Complete Structure Elucidation of Maitotoxin
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批准号:06453211
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资助金额:$3.07万
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财政年份:1994
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负责人:MURATA Michio
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依托单位:
海外基金