Functional Control by Modulating the Nucleic Acid Structure Based on Mismatch Base Pair Stabilization
Functional Control by Modulating the Nucleic Acid Structure Based on Mismatch Base Pair Stabilization
批准号:
18105006
负责人:
NAKATANI Kazuhiko
金额:
$72.38万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2010
中文摘要
我们已经建立了一个新的概念,即小的合成配体选择性地与DNA错配结合,可以控制DNA的高阶结构。DNA杂交可以由新开发的光响应错配结合配体可逆地控制,这使得我们可以根据配体指定的DNA结构来调节各种基于DNA的功能。
英文摘要
We have established novel concept that small synthetic ligand, which selectively binds to DNA mismatch, could control higher order structures of DNA. DNA hybridization could be reversibly controlled by newly developed photoresponsive mismatch binding ligand, which allowed us to modulate various DNA-based functions depending on the ligand-specified DNA structures.
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发表时间:
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发表时间:
2009
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影响因子:
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共 25 条
Chemical Biology Studies on Trinucleotide Repeat Disease using Repeat-Binding Molecules
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Regulation of secondary structure by RNA loop-loop interaction inducedsmall molecular binding
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Modulation of DNA mediated hole transport by novel substituents on DNA
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Studies on a rapid detection system of SNPs using mismatch-binding molecules
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Molecular Design of Nobel DNA Alkylating Agent at GG step
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负责人:NAKATANI Kazuhiko
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