Comparing properties of innate immune proteins of bats and humans

比较蝙蝠和人类先天免疫蛋白的特性

• 批准号: DP240103205
• 负责人: A/Prof Yann Gambin
• 金额: $ 36.47万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240103205
• 关键词: Comparing; properties; innate; immune; proteins

Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the “supra-immunity” of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms that regulate the signalosomes. The intended outcome is to answer the long-standing question of control of speed and amplitude of innate immune response at the molecular level. Both locally and internationally, this new approach should provide benefits across structural biology, molecular evolution and biotechnology.

被称为信号体的超分子蛋白质复合物通过形成能够招募下游效应物的大型信号枢纽来驱动我们的先天免疫反应。本项目旨在比较人类和蝙蝠信号体的性质和结构，并发现蝙蝠“超免疫”的分子起源。在这种情况下，该项目预计将产生有关调节信号体的基本分子机制的新知识。预期的结果是回答长期存在的问题，在分子水平上控制先天免疫反应的速度和幅度。无论是在本地还是在国际上，这种新方法都将为结构生物学、分子进化和生物技术带来好处。