Study of Oxytocin Receptor on Regulation of Social Behaviors and Body Temperature Control

催产素受体对社会行为调节和体温控制的研究

• 批准号: 18380063
• 负责人: NISHIMORI Katsuhiko
• 金额: $ 10.07万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18380063/
• 关键词: Oxytocin receptor; Gene KO Mice; Maternal Behaviors; Social behaviors; Neurohypophysial Hormones; Venus; PWS; Necdin

An imaging spectrometer system was employed to measure two-dimensional emission images from a glow discharge plasma in atomic emission spectrometry. Emission signals from a glow discharge lamp having a hollow anode of 8 mm in diameter were conducted through a collimator optics onto the entrance slit of an imaging spectrograph (Model 12580, BunkoKeiki Corp.), and the emission image was then dispersed and detected on a CCD detector (SensiCam QE Model, PCO Imaging Corp.). The emission images at Zn I 334.50 nm for a zinc sample and at Cu I 324.75 nm for a copper sample could be obtained. Their emission intensities were not uniform in the radial direction of the plasma region but became weaker at larger distance from the central zone. The two-dimensional distribution would result from a spatial variation in the excitation effciency of the plasma. Temporal variations in the emission images were also observed when a zinc-coated steel plate and a thermally-deposited copper film were employed as the sample. Depth profiles of these surface layers estimated from the corresponding images indicated that a spatially-resolved measurement could provide the data with good precision.

利用原子发射光谱成像光谱仪系统测量了辉光放电等离子体的二维发射图像。来自具有直径为8mm的中空阳极的辉光放电灯的发射信号通过准直器光学器件传导到成像光谱仪（Model 12580，BunkoKeiki Corp.）的入口狭缝上，然后将发射图像分散并在CCD检测器（SensiCam QE Model，PCO Imaging Corp.）上检测。可以获得锌样品在Zn I 334.50 nm处的发射图像和铜样品在Cu I 324.75 nm处的发射图像。它们的发射强度在等离子体区域的径向方向上是不均匀的，但在离中心区较远的地方变得较弱。二维分布是由等离子体激发效率的空间变化引起的。当采用镀锌钢板和热沉积铜膜作为样品时，还观察到发射图像的时间变化。从相应的图像估计的这些表面层的深度剖面表明，空间分辨的测量可以提供具有良好精度的数据。

项目成果

Oxytocin receptor-Venus knock-in mice enable direct visualization of oxytocin receptor-expressing neurons

催产素受体-金星敲入小鼠能够直接观察表达催产素受体的神经元

• 发表时间: 2007
• 作者: Yoshida;M.;ed. al.
• 通讯作者: ed. al.

Study of oxytocin receptor in themoregulation using the gene KO mice

基因KO小鼠催产素受体体温调节研究

• 发表时间: 2007
• 作者: Kasahara;Y.;ed. al.
• 通讯作者: ed. al.

IMPAIRED THERMOREGULATORY ABILITY OF OXYTOCIN AND OXYTOCIN RECEPTOR DEFICIENT MICE DURING COLD-EXPOSURE

冷暴露期间催产素和催产素受体缺陷小鼠的体温调节能力受损

• 发表时间: 2008
• 作者: Soto;K.;ed. al.
• 通讯作者: ed. al.

Study of physiological and behavioral functions of receptor with mice whose Oxtr genes were modified

Oxtr基因修饰小鼠受体生理及行为功能研究

• 发表时间: 2007
• 作者: 西森克彦;他
• 通讯作者: 他

Eye-open at birth phenotype with reduced keratinocyte motility in LGR4 null mice

• DOI: 10.1016/j.febslet.2007.08.064
• 发表时间: 2007-10-02
• 期刊: FEBS LETTERS
• 影响因子: 3.5
• 作者: Kato, Shigeki;Mohri, Yasuaki;Nishimori, Katsuhiko
• 通讯作者: Nishimori, Katsuhiko