Study of novel physiological function by the system with oxytocin and its receptor.

催产素及其受体系统新生理功能的研究。

• 批准号: 23380055
• 负责人: NISHIMORI Katsuhiko
• 金额: $ 11.9万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23380055/
• 关键词: 情報伝達; オキシトシン受容体; オキシトシン; 社会行動; 自閉症スペクトラム; 母性行動; 扁桃体内側核; セロトニン; グリア細胞; 向社会行動; 自閉症; 外側中隔; 体温制御

Central oxytocin and its receptor Oxtr have a regulatory function to control social behaviors in mammals, including human. Also, application of oxytocin to Autism patients have been started and reports describing positive cure effects have been accumulated. In this study, we analyzed the mechanism controlling social behaviors by neurons expressing Oxtr in brain First, by crossing fx-type Oxtr KO mice with ePet-Cre mice, we generated mice having 5-HT neurons-specific deletion of Oxtr genes. This line didn't show any impairment in their social memory. In contrast, rescue experiment was carried out by injection of AAV-Cre viral vector to mice brains to induce MeA-specific deletion of Oxtr gene, and it revealed that Oxtr expressing in MeA were essential for social memory. In addition, we found that the glutamatergic neurons expressing Oxtr in rRPa regulated body temperature. We forwarded study of type I taste cells expressing Oxtr, and obtained novel characteristics of these populations.

中枢催产素及其受体Oxtr对包括人类在内的哺乳动物的社会行为具有调节作用。此外，已经开始将催产素应用于自闭症患者，并且已经积累了描述积极治疗效果的报告。在本研究中，我们分析了大脑中表达Oxtr的神经元控制社会行为的机制。首先，通过将fx型Oxtr KO小鼠与ePet-Cre小鼠杂交，我们产生了具有5-HT神经元特异性Oxtr基因缺失的小鼠。这条线并没有显示出他们的社会记忆有任何损伤。相反，通过向小鼠脑内注射AAV-Cre病毒载体进行拯救实验，诱导MeA特异性缺失Oxtr基因，结果表明MeA中表达的Oxtr对社会记忆是必需的。此外，我们发现rRPa中表达Oxtr的丘脑能神经元调节体温。我们对表达Oxtr的I型味觉细胞进行了研究，并获得了这些群体的新特征。

项目成果

Involvement of prolactin-releasing peptide in the activation of oxytocin neurones in response to food intake.

• DOI: 10.1111/jne.12019
• 发表时间: 2013-05
• 期刊: Journal of neuroendocrinology
• 影响因子: 3.2
• 作者: Yamashita M;Takayanagi Y;Yoshida M;Nishimori K;Kusama M;Onaka T
• 通讯作者: Onaka T

Fear-enhancing effects of septal oxytocin receptors.

• DOI: 10.1038/nn.3465
• 发表时间: 2013-09
• 期刊: NATURE NEUROSCIENCE
• 影响因子: 25
• 作者: Guzman, Yomayra F.;Tronson, Natalie C.;Jovasevic, Vladimir;Sato, Keisuke;Guedea, Anita L.;Mizukami, Hiroaki;Nishimori, Katsuhiko;Radulovic, Jelena
• 通讯作者: Radulovic, Jelena

Role of oxytocin receptors in modulation of fear by social memory.

• DOI: 10.1007/s00213-013-3356-6
• 发表时间: 2014-05
• 期刊: PSYCHOPHARMACOLOGY
• 影响因子: 3.4
• 作者: Guzman, Yomayra F.;Tronson, Natalie C.;Sato, Keisuke;Mesic, Ivana;Guedea, Anita L.;Nishimori, Katsuhiko;Radulovic, Jelena
• 通讯作者: Radulovic, Jelena

LGR4欠損マウスにおける雌生殖器の雄化

LGR4缺陷小鼠雌性生殖器官的男性化

• 发表时间: 2012
• 作者: 鈴木史朗;柴田清住;吉川聡明;中面哲也;吉川史隆;小泉雅江;小泉雅江;小泉雅江;小泉雅江;小泉雅江;小泉雅江
• 通讯作者: 小泉雅江

絆を支える神経修飾因子、オキシトシンと受容体

催产素和受体、支持联系的神经调节剂

• 发表时间: 2013
• 作者: 大杉桂奈江;井元千晶;柴田秀樹;牧正敏;西森克彦
• 通讯作者: 西森克彦