Clarification of the mechanisms of cardiovascular dysfunction and the resultant organ failure

阐明心血管功能障碍和由此导致的器官衰竭的机制

基本信息

项目摘要

Accumulating evidence suggests significance of the oxidized LDL receptor LOX-1 in endothelial and vascular dysfunction. In this study, we generated LOX-1 KO mice to address the role of LOX-1 in atherosclerotic diseases. With the KO mice, we obtained following results. (1) LOX-1 KO mice were resistant to the suppressive effects of oxidized LDL on endothelium-dependent relaxation. (2) Atherosclerosis induced by high fat diet was delayed in LOX-1 KO mice compared with wild type mice in both C57BL/6 and LDLRKO-C57BL/6 background. (3) Myocardial infarction and cardiac remodeling induced by LASD ligation was suppressed and cardiac function was relatively preserved in LOX-1 KO mice compared with wild type. (4) Both platelet aggregation in vitro and FeC12-induced thrombosis in vivo were suppressed in LOX-1 KO mice compared with wild type. Thus, we have demonstrated that LOX-1 aggravates every phase of atherosclerotic diseases, i.e. endothelial dysfunction, atherosclerosis, thrombosis, and myocardial infarction.
越来越多的证据表明氧化 LDL 受体 LOX-1 在内皮和血管功能障碍中的重要性。在这项研究中,我们培育了 LOX-1 KO 小鼠,以研究 LOX-1 在动脉粥样硬化疾病中的作用。通过 KO 小鼠,我们获得了以下结果。 (1) LOX-1 KO 小鼠对氧化 LDL 对内皮依赖性舒张的抑制作用具有抵抗力。 (2)在C57BL/6和LDLRKO-C57BL/6背景下,与野生型小鼠相比,LOX-1 KO小鼠高脂饮食诱导的动脉粥样硬化延迟。 (3)与野生型相比,LOX-1 KO小鼠LASD结扎诱导的心肌梗死和心脏重塑受到抑制,心功能相对保留。 (4)与野生型相比,LOX-1 KO小鼠体外血小板聚集和FeCl2诱导的体内血栓形成均受到抑制。因此,我们证明LOX-1会加重动脉粥样硬化疾病的各个阶段,即内皮功能障碍、动脉粥样硬化、血栓形成和心肌梗塞。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Oxidized LDL binding to LOX-1upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gamma.
氧化 LDL 与 LOX-1 结合,通过激活 PPAR-gamma 上调培养牛软骨细胞中 VEGF 的表达。
LOX-1 deletion alters signals of myocardial remodeling immediately after ischemia-reperfusion
  • DOI:
    10.1016/j.cardiores.2007.07.003
  • 发表时间:
    2007-11-01
  • 期刊:
  • 影响因子:
    10.8
  • 作者:
    Hu, Changping;Dandapat, Abhijit;Mehta, Jawahar L.
  • 通讯作者:
    Mehta, Jawahar L.
Lectin-like oxidized LDL receptor-1 as extracellular chaperone receptor : Its versatile functions and human diseases.
凝集素样氧化 LDL 受体 1 作为细胞外伴侣受体:其多功能功能与人类疾病。
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Inoue;N. and Sawamura;T.
  • 通讯作者:
    T.
Dominant-Negative Lox-1 Blocks Homodimerization of Wild-Type Lox-1–Induced Cell Proliferation Through Extracellular Signal Regulated Kinase 1/2 Activation
  • DOI:
    10.1161/01.hyp.0000229825.98545.5e
  • 发表时间:
    2006-08
  • 期刊:
  • 影响因子:
    8.3
  • 作者:
    H. Tanigawa;S. Miura;Yoshino Matsuo;M. Fujino;T. Sawamura;K. Saku
  • 通讯作者:
    H. Tanigawa;S. Miura;Yoshino Matsuo;M. Fujino;T. Sawamura;K. Saku
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SAWAMURA Tatsuya其他文献

SAWAMURA Tatsuya的其他文献

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{{ truncateString('SAWAMURA Tatsuya', 18)}}的其他基金

Elucidation of physiological significance of LOX-1 binding molecules
LOX-1结合分子的生理意义的阐明
  • 批准号:
    25293063
  • 财政年份:
    2013
  • 资助金额:
    $ 10.77万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Pathophysiological significance of the factor which enhances the action of oxidized LDL, platelets, and leukocytes on vascular wall.
增强氧化低密度脂蛋白、血小板和白细胞对血管壁作用的因子的病理生理学意义。
  • 批准号:
    22390051
  • 财政年份:
    2010
  • 资助金额:
    $ 10.77万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
STUDY ON THE SIGNIFICANCE OF LOX-1 IN OXIDATIVE STRESS-RELATED BIOLOGICAL RESPONSES
LOX-1在氧化应激相关生物反应中的意义研究
  • 批准号:
    16390070
  • 财政年份:
    2004
  • 资助金额:
    $ 10.77万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Investigations for developing novel diagnostic methods, therapeutics, and drugs utilizing lectin-like oxidized LDL receptor-1 (LOX-1)
利用凝集素样氧化 LDL 受体 1 (LOX-1) 开发新型诊断方法、治疗方法和药物的研究
  • 批准号:
    11557006
  • 财政年份:
    1999
  • 资助金额:
    $ 10.77万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)

相似海外基金

Cell-free hemoglobin-oxidized LDL-LOX-1 axis and microvascular hyperpermeability during sepsis
脓毒症期间无细胞血红蛋白氧化的 LDL-LOX-1 轴和微血管通透性过高
  • 批准号:
    10739620
  • 财政年份:
    2023
  • 资助金额:
    $ 10.77万
  • 项目类别:
Oxidized LDL dependent reprogramming of the liver lymphatic endothelium
氧化LDL依赖性肝淋巴内皮重编程
  • 批准号:
    10596498
  • 财政年份:
    2020
  • 资助金额:
    $ 10.77万
  • 项目类别:
Oxidized LDL dependent reprogramming of the liver lymphatic endothelium
氧化LDL依赖性肝淋巴内皮重编程
  • 批准号:
    10371256
  • 财政年份:
    2020
  • 资助金额:
    $ 10.77万
  • 项目类别:
Oxidized LDL dependent reprogramming of the liver lymphatic endothelium
氧化LDL依赖性肝淋巴内皮重编程
  • 批准号:
    10176480
  • 财政年份:
    2020
  • 资助金额:
    $ 10.77万
  • 项目类别:
Oxidized LDL dependent reprogramming of the liver lymphatic endothelium
氧化LDL依赖性肝淋巴内皮重编程
  • 批准号:
    10028083
  • 财政年份:
    2020
  • 资助金额:
    $ 10.77万
  • 项目类别:
Analysis and application of carbohydrate binding specificity of oxidized LDL receptor
氧化型LDL受体碳水化合物结合特异性分析及应用
  • 批准号:
    19K05886
  • 财政年份:
    2019
  • 资助金额:
    $ 10.77万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Effects of syncytiotrophoblast extracellular vesicles on angiotensin II-induced vasoconstriction in uterine arteries from lectin-like oxidized LDL receptor-1 overexpressing mice
合体滋养层细胞外囊泡对血管紧张素 II 诱导的凝集素样氧化 LDL 受体 1 过表达小鼠子宫动脉血管收缩的影响
  • 批准号:
    400208
  • 财政年份:
    2019
  • 资助金额:
    $ 10.77万
  • 项目类别:
Quantitative method of oxidized LDL in blood using high-functional peptides and its application to in vitro diagnosis
高效能肽定量测定血液中氧化LDL及其在体外诊断中的应用
  • 批准号:
    16K19201
  • 财政年份:
    2016
  • 资助金额:
    $ 10.77万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
The origin of the oxidized LDL in arterial wall in the cause of cerebral vasospasm
动脉壁氧化LDL导致脑血管痉挛的根源
  • 批准号:
    15K19947
  • 财政年份:
    2015
  • 资助金额:
    $ 10.77万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Studies on process of generation and metabolism of oxidized LDL in vivo.
体内氧化型低密度脂蛋白生成及代谢过程的研究。
  • 批准号:
    15K07944
  • 财政年份:
    2015
  • 资助金额:
    $ 10.77万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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