A Comprehensive Study of Pathological Significance of Atypical Cytosine Methylation during Tumorigenesis and Progression

肿瘤发生发展过程中非典型胞嘧啶甲基化病理学意义的综合研究

• 批准号: 18390114
• 负责人: MAEDA Sakan
• 金额: $ 9.97万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390114/
• 关键词: エピジェネティクス; in situ hybridization; 非CpGアイランド; メチル化シトシン; 遺伝子プロモータ; 膀胱癌; BANBI; 転写制御; BAMBI; 非CpG-island; 膵癌; TrkA

While cytosine methylation in CpG-island, located usually regulatory region of many genes, is well recognized as an inhibitory epigenetic regulator, biological significance of the cytosine methylation other than CpG-island is unclear. By focusing morphology-oriented microscopic dissection methods, we investigated cytosine methylation status in the gene promoter, and found that some of the cytosine methylation outside of the CpG-island have major contributions during cancer progression.

CpG岛通常位于许多基因的调控区域，其胞嘧啶甲基化被公认为是一种抑制性表观遗传调节因子，但除CpG岛以外的胞嘧啶甲基化的生物学意义尚不清楚。通过聚焦形态学导向的显微解剖方法，我们研究了基因启动子中的胞嘧啶甲基化状态，发现CpG岛以外的一些胞嘧啶甲基化在癌症进展中具有重要作用。

项目成果

MeCP2 expression and promoter methylation of cyclin D1 gene are associated with cyclin D1 expression in developing rat epididymal duct.

Cyclin D1基因的MECP2表达和启动子甲基化与Cyclin d1表达在发育中的大鼠附子导管中有关。

• DOI: 10.1267/ahc.08025
• 发表时间: 2008-10-29
• 期刊: ACTA HISTOCHEMICA ET CYTOCHEMICA
• 影响因子: 2.4
• 作者: Darwanto, Agus;Kitazawa, Riko;Mori, Kiyoshi;Kondo, Takeshi;Kitazawa, Sohei
• 通讯作者: Kitazawa, Sohei

FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets

• DOI: 10.1172/jci34090
• 发表时间: 2008-08-01
• 期刊: JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 15.9
• 作者: Nishino, Naonobu;Tamori, Yoshikazu;Kasuga, Masato
• 通讯作者: Kasuga, Masato

Lipopolysaccharide suppresses RANK gene expression by macrophage through the down-regulation of PU.1 and MITF

脂多糖通过下调 PU.1 和 MITF 抑制巨噬细胞的 RANK 基因表达

• 发表时间: 2008
• 期刊: J Cell Biochem 105
• 作者: Ishii J.;et al.
• 通讯作者: et al.

Leopairat J, Hypermethylation of Epithelial-cadherin Gene Promoter is Associated with Epstein-Barr Virus in Nasopharyngeal Carcinoma

Leopairat J，鼻咽癌中上皮钙粘蛋白基因启动子的高甲基化与 Epstein-Barr 病毒相关

• 发表时间: 2008
• 期刊: Cancer Detect Prev 32
• 作者: Niemhom S;Kitazawa S;Kitazawa R;Maeda S
• 通讯作者: Maeda S

Regulation of Osteoclastogenesis by CpG Methylation of Mouse Receptor Activator of NF-kB Ligand(RANKL)Gene Promoter Region

小鼠NF-kB配体受体激活剂(RANKL)基因启动子区CpG甲基化对破骨细胞生成的调节

• 发表时间: 2006
• 作者: Kitazawa R;Mori K;Kondo T;Kitazawa S
• 通讯作者: Kitazawa S