A Comprehensive Study of Pathological Significance of Atypical Cytosine Methylation during Tumorigenesis and Progression

胞嘧啶甲基化通常位于许多基因的调控区域，被认为是一种抑制性表观遗传调节剂，但胞嘧啶甲基化除cpg岛外的生物学意义尚不清楚。通过聚焦形态学取向的显微解剖方法，我们研究了基因启动子中的胞嘧啶甲基化状态，发现cpg岛外的一些胞嘧啶甲基化在癌症进展中起主要作用。

While cytosine methylation in CpG-island, located usually regulatory region of many genes, is well recognized as an inhibitory epigenetic regulator, biological significance of the cytosine methylation other than CpG-island is unclear. By focusing morphology-oriented microscopic dissection methods, we investigated cytosine methylation status in the gene promoter, and found that some of the cytosine methylation outside of the CpG-island have major contributions during cancer progression.