Dynamics of circulating rotavirus strains after vaccine introduction in Brazil.

巴西引入疫苗后循环轮状病毒株的动态。

• 批准号: 18406016
• 负责人: NAKAGOMI Toyoko
• 金额: $ 9.38万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18406016/
• 关键词: ロタウイルス; ワクチン; 血清型; 有効性; 異型免疫; 流行株; G2P[4]; ブラジル; 分子疫学; 遺伝子型; 防御免疫; ロタウイルスワクチン; 新興株; 抗原変異

We observed an abrupt increase of G2P[4] strains in Brazil after the introduction of the monovalent G1P[8] rotavirus vaccine. In clinical trials, the effectiveness of the monovalent vaccine against fully-heterotypic G2P[4] strains was not well established because the circulating strains at the time of clinical trials were mainly G1P[8] strains. Thus, this study was undertaken to assess the vaccine effectiveness against G2P[4] strains using the case-control design. Among children aged 6-11 months, the effectiveness of the monovalent vaccine was 77% against severe G2P[4] diarrhoea, and 83-85% against hospitalization. The G1P[8] monovalent vaccine was shown to be effective against severe diarrhoea due to G2P[4] rotavirus strains in an impoverished setting in Latin America.

我们观察到，在引入单价G1P[8]轮状病毒疫苗后，巴西的G2P[4]毒株突然增加。在临床试验中，由于临床试验时流行的菌株主要是G1P[8]菌株，单价疫苗对完全异型G2P[8]菌株的有效性尚未得到很好的确定。因此，本研究采用病例对照设计来评估疫苗对G2P[4]菌株的有效性。在6-11个月的儿童中，单价疫苗对严重腹泻的有效性为77%，对住院治疗的有效性为83-85%。在拉丁美洲的贫困环境中，G2P[8]单价疫苗被证明对G2P[8]轮状病毒株引起的严重腹泻有效。

项目成果

定期接種導入後のブラジルにおけるロタウイルスワクチンのインパクト

常规疫苗接种后巴西轮状病毒疫苗的影响

• 发表时间: 2007
• 作者: Furukawa;A.;et. al.;中込 とよ子
• 通讯作者: 中込 とよ子

Effectiveness of Monovalent Rotavirus Vaccine (Rotarix) against Severe Diarrhea Caused by Serotypically Unrelated G2P[4] Strains in Brazil

• DOI: 10.1086/649843
• 发表时间: 2010-02-01
• 期刊: JOURNAL OF INFECTIOUS DISEASES
• 影响因子: 6.4
• 作者: Correia, Jailson B.;Patel, Manish M.;Nakagomi, Toyoko
• 通讯作者: Nakagomi, Toyoko

ロタウイルス感染症

轮状病毒感染

• 发表时间: 2008
• 期刊: 最新医学 63
• 作者: 中込とよ子;中込治
• 通讯作者: 中込治

Issues with reducing the rotavirus-associated mortality by accination in developing countries

发展中国家通过接种疫苗降低轮状病毒相关死亡率的问题

• 发表时间: 2008
• 期刊: Vaccine 26
• 作者: Naghipour M;Nakagomi T;Nakagomi O
• 通讯作者: Nakagomi O

Anticipating rotavirus vaccines in Brazil : detection and molecular characterization of emerging rotavirus serotypes G8 and G9 among children with diarrhoea in Recife

巴西轮状病毒疫苗的预期：累西腓腹泻儿童中新出现的轮状病毒血清型 G8 和 G9 的检测和分子特征分析

• 发表时间: 2007
• 期刊: Brazil. J Med Virol 79
• 作者: Montenegro FM;Correia JB;Rodrigues Falbo A;Dove W;Nakagomi T;Nakagomi O;Cuevas LE;Cunliffe NA;Hart CA
• 通讯作者: Hart CA