Etiology and teratment of acute tubular necrosis on peritubular capillary microcirculation

我们从临床治疗药物中筛选出具有保护血管内皮细胞能力的药物作为治疗急性肾小管坏死的药物。采用铅笔镜、CCD视频显微镜(PLCVM)成像技术，结合病理生化检查，对大鼠肾缺血再灌注模型肾小管周围毛细血管血流进行评价，筛选出治疗心力衰竭的药物奥利普隆和治疗弥漫性血管内凝血的治疗药物凝血酶原激活剂，具有肾脏保护作用。提示这些临床药物对急性肾小管坏死大鼠修复融合模型具有微循环保护作用，近期将用于急性肾小管坏死患者。

We selected from clinical treatment drug with ability of prorecting vascular endthelial cells as treatment drug for acute tubular necrosis. Oliprinone as treatment drug of heart failure and thrombmodulin as treatment drug of disseminated inravascular coagulation were selected from evaluating on peritubular capillary flow of ischemic reperfusion rat model by pencil lens CCD video-microscopy(PLCVM) imaging technique adition to pathological and biochemical examinations resulting in having ability of renal protecting effect. It revealed that these clinical drugs have effect of protecting the microcirculation for rat repaerfusion model as acute tubular necrosis.Near future, these clinical drugs with effect of renal microcirculatory protect will be used for patients with acute tubular necrosis.