Niche of treatment of adiposed drived stem cell for renal damage by low serum culture

急性肾损伤（AKI）是一个主要的临床问题，具有高死亡率和有限的病因治疗。细胞治疗已被认为是改善AKI病程和预后的一种潜在方法，我们研究了低血清培养的脂肪组织来源的干细胞和再生细胞（ADRCs）在大鼠AKI缺血-再灌注（I-R）模型中的可能肾脏保护作用。ADRC组血清肌酐、尿素氮明显低于对照组。ADRCs组肾小管周血流量较对照组增加。总的来说，这些结果表明ADRC治疗在AKI患者中具有潜在的临床作用。

Acute kidney injury (AKI) represents a major clinical problem with high mortality and limited causal treatments. The use of cell therapy has been sug- gested as a potential modality to improve the course and outcome of AKI.We investigated the possible renoprotection of low serum cultured adipose tissue-derived stem and regenerative cells (ADRCs) in a rat ischemia-reperfusion (I-R) model of AKI. We demonstrated that ADRC group drastically significantly reduced than control group serum creatinine and BUN. In adition, ADRCs group increased than control group in peritubular blood flow. Collectively, these results suggest a potential clinical role for ADRC therapy in patients with AKI.