Research for erectile dysfunction by DNA microarray assay and PWV/PVM

勃起功能障碍主要是由于阴茎海绵体平滑肌不能完全放松所致。在衰老大鼠模型中，勃起功能障碍伴随着阴茎平滑肌顺应性的减少，并且在非常年老的动物中，阴茎一氧化氮合酶（NOS）的减少，NOS负责合成阴茎勃起介质一氧化氮（NO）。我们检测了糖尿病大鼠和同窝对照大鼠阴茎基因表达的变化。使用Affymetrix基因芯片阵列和统计滤波。动脉粥样硬化相关基因引起血管内皮功能障碍，是心血管疾病的主要危险因素。这项研究的数据有助于理解微循环障碍的病理生理作用机制，特别是内皮功能和动脉粥样硬化的发病机制。CYP3A雌激素/睾酮失活相关信息与勃起功能障碍和LOH状况密切相关。数据表明，假定的动脉粥样硬化负荷（通过勃起功能障碍危险因素和事件的数量来评估）与基于主动脉脉搏波速度测量的无创主动脉顺应性之间存在显著的反比关系。勃起功能障碍的危险表现为早期心血管危险因素的外在症状。如果这些发现得到前瞻性、纵向随访研究的证实，这些测量可能被证明是血管风险的非侵入性标志物。

Erectile dysfunction is mainly due to the inability of the cavernosal smooth muscle of the penis to undergo complete relaxation. In the aging rat model, erectile dysfunction is accompanied by a reduction of penile smooth muscle compliance and, in very old animals, by a decrease in penile nitric oxide synthase (NOS), which is responsible for the synthesis of the mediator of penile erection, nitric oxide (NO).we examined alterations in penile gene expression in diabetic rats and littermate controls. With the use of Affymetrix GeneChip arrays and statistical filtering. Athelosclerosis related genes cause vascular endothelial dysfunction and is a major risk factor for cardiovascular diseases. The data from this study are relevant to understanding the mechanisms underlying the pathophysiological effect of microcirculation disorder, particularly on endothelial function and pathogenesis of atherosclerosis. CYP3A correlated information about inactivating action of estrogen/testosterone has close relationship with erectile dysfunction and LOH conditions. The data suggest that a significant inverse relation exists between presumed atherosclerotic load (as assessed by the number of erectile dysfunction risk factors and events) and aortic compliance determined noninvasively based on aortic pulse wave velocity measurements. Erectile dysfunction risk shows outward symptom during the early stage of cardiovascular risk factors. If these findings are confirmed by prospective, longitudinal follow-up studies, such measurements may prove useful as a noninvasive marker of vascular risk.