Research for erectile dysfunction by DNA microarray assay and PWV/PVM

勃起功能障碍的主要原因是阴茎阴茎海绵体平滑肌不能完全放松。在老龄大鼠模型中，勃起功能障碍伴随着阴茎平滑肌顺应性的降低，在非常年长的动物中，伴随着阴茎一氧化氮合酶(NOS)的减少，而一氧化氮合酶(NOS)是阴茎勃起的中介物质，一氧化氮(NO)的合成。使用Affymetrix基因芯片阵列和统计过滤。运动硬化相关基因导致血管内皮细胞功能障碍，是心血管疾病的主要危险因素。这项研究的数据对于了解微循环障碍的病理生理影响的机制，特别是对内皮功能和动脉粥样硬化的发病机制具有重要意义。雌激素/睾酮失活的相关信息与勃起功能障碍和LOH状态密切相关。这些数据表明，假设的动脉粥样硬化负荷(通过勃起功能障碍危险因素和事件的数量来评估)与基于主动脉脉搏波速度测量的非侵入性确定的主动脉顺应性之间存在显着的负相关。勃起功能障碍风险在心血管危险因素的早期阶段表现为外在症状。如果这些发现被前瞻性的纵向随访研究证实，这种测量可能被证明是有用的血管风险的非侵入性标记。

Erectile dysfunction is mainly due to the inability of the cavernosal smooth muscle of the penis to undergo complete relaxation. In the aging rat model, erectile dysfunction is accompanied by a reduction of penile smooth muscle compliance and, in very old animals, by a decrease in penile nitric oxide synthase (NOS), which is responsible for the synthesis of the mediator of penile erection, nitric oxide (NO).we examined alterations in penile gene expression in diabetic rats and littermate controls. With the use of Affymetrix GeneChip arrays and statistical filtering. Athelosclerosis related genes cause vascular endothelial dysfunction and is a major risk factor for cardiovascular diseases. The data from this study are relevant to understanding the mechanisms underlying the pathophysiological effect of microcirculation disorder, particularly on endothelial function and pathogenesis of atherosclerosis. CYP3A correlated information about inactivating action of estrogen/testosterone has close relationship with erectile dysfunction and LOH conditions. The data suggest that a significant inverse relation exists between presumed atherosclerotic load (as assessed by the number of erectile dysfunction risk factors and events) and aortic compliance determined noninvasively based on aortic pulse wave velocity measurements. Erectile dysfunction risk shows outward symptom during the early stage of cardiovascular risk factors. If these findings are confirmed by prospective, longitudinal follow-up studies, such measurements may prove useful as a noninvasive marker of vascular risk.