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Prospective study for detecting risk factors ineluding serum placental growth factor (PIGT) for the occurrence ofearly onset preeclampsia

血清胎盘生长因子（PIGT）等早发性子痫前期危险因素检测的前瞻性研究

基本信息

批准号：
18591809
负责人：
OHKUCHI Akihide
金额：
$ 2.57万
依托单位：
Jichi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

We examined uterine artery flow velocity waveforms in 1500 pregnant women at 16 to 23 weeks of gestation, during April 2003 to March 2008. We also took 10m1 of blood from 1358, 916 and 365 pregnant women at 20 to 23, 28 to 29, and 37 weeks of gestation, respectively, and centrifuged the blood, and stored the serums and plasmas at -20 C until the examination of placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1). We obtained the following 3 main results during 2 years.1. We investigated 587 pregnant cohorts, and examined the effects of the high notch depth index (NDI) of the uterine flow velocity waveforms around 20 weeks of gestation and blood pressure levels around 20 week of gestation on the later occurrence of preeclampsia. The sensitivities of high NDI and the existence of prehypertension (>130/85 mmHg)/hypertension were 53% and 63%, respectively. The combination of both markers resulted in the increase of sensitivity (84%)2. We investigated 261 singleton … More pregnant cohorts, who were examined uterine artery flow velocity waveforms at 16 to 23 weeks of gestation, and in whom serum levels of P1GF and sFlt-1 twice at both 16 to 23 and 27 to 29 weeks of gestation. In women with high NDI at mid-gestation, the serum levels of P1GF were significantly low. In addition, the incidence rates of high sFlt-1 levels at around 28 weeks of gestation and the later occurrence of preeclampsia were significantly higher in women with both high NDI and low P1GF levels, than those with both low NDI and high P1GF, those with both low NDI and low P1GF, and those with both high NDI and high P1GF, respectively.3. We established the normal reference values of serum soluble endoglin (sEng) from 20 to 38 weeks of gestation, using serums taken three times at 20 to 23, 27 to 29 and 36 to 38 weeks of gestation in 85 normal pregnant women. We found that all the women (25/25) with early onset preeclampsia showed high sEng (≧ 95% of the reference ranges of sEng during pregnant period), and all the women (5/5) with later occurrence of early onset preeclampsia showed high sEng at 16 to 23 weeks of gestation. Less

在2003年4月至2008年3月期间，我们检测了1500名怀孕16至23周的孕妇的子宫动脉流速波形。1358例、916例和365例妊娠20 ~ 23周、28 ~ 29周和37周的孕妇，分别取10m1血，离心，血清和血浆-20℃保存，待检测胎盘生长因子（PlGF）和可溶性纤维样酪氨酸激酶1 （sFlt-1）。2年来，我们取得了以下3个主要成果：1。我们调查了587例妊娠队列，研究了妊娠20周前后子宫流速波形的高缺口深度指数（NDI）和妊娠20周前后血压水平对子痫前期后期发生的影响。高NDI和存在高血压前期(>130/85 mmHg)/高血压的敏感性分别为53%和63%。两种标志物联合使用可提高敏感性（84%）2。我们调查了261个单胎妊娠队列，在妊娠16 - 23周检查子宫动脉流速波形，在妊娠16 - 23周和27 - 29周两次检测血清P1GF和sFlt-1水平。在妊娠中期NDI高的妇女，血清P1GF水平明显较低。此外，在妊娠28周左右，高NDI和低P1GF的妇女中，高sFlt-1水平的发生率和后来发生子痫前期的发生率分别显著高于低NDI和高P1GF、低NDI和低P1GF以及高NDI和高P1GF的妇女。我们建立了妊娠20至38周血清可溶性内啡肽（sEng）的正常参考值，使用85名正常孕妇妊娠20至23周、27至29周和36至38周三次血清。我们发现所有早发型子痫前期女性（25/25）在妊娠期均有较高的sEng(≧95%)，所有晚发型早发型子痫前期女性（5/5）在妊娠16 ~ 23周均有较高的sEng。少