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Boron Neutron Capture Therapy for Head and Neck Epithelial Carcinomas

硼中子捕获疗法治疗头颈上皮癌

基本信息

批准号：
18591898
负责人：
AIHARA Teruhito
金额：
$ 2.36万
依托单位：
Kawasaki Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591898/
关键词：
advanced epithelial carcinoma BNCT BPA 18F-BPA-PET study T N ratio N比進行頭頚部癌 18F-BPA PET ^<18>F-BPA PET

项目摘要

[Background]Based on the reports that success of BNCT in treating mucoepidermoid carcinoma of the parotid gland, we have been conducting BNCT clinical trial on recurrence or locally advanced epithelial carcinomas in the head and neck since October 2003.[Patients and Methods]Three patients were treated with BNCT at KUR or JRR-4 from October 2003 to September 2007. The histologic type of carcinoma, primary region, and TNM staging in each patient were as follows : Patient 1 : acinic cell carcinoma ; palotid gland ; T4N0M0, Patient 2 : ACC ; lacrimal sac ; T4N0M0, Patient 3:ACC ; maxillary sinus ; T4N0M0.The tumor/normal-tissue boron concentration ratio (T/N ratio) obtained from 18F-BPA-PEP study was adopted to the dose estimation before neutron irradiation and dose evaluation after BNCT using SERA or JCDS. Neutron irradiation was performed using an epithermal beam at a reactor power of 5.0 MW (KUR) or 3.5 MW (JRR-4) after intravenous administration of BPA in fructose solution at a dose of 500 mg/kg body weight. The tumor dose at the deepest part and the dose of both normal skin and mucosa were planned more than 20 Gy-Eq and less than 15 Gy-Eq, respectively.[Results]All patients demonstrated regional complete response (CR). All patient suffered from dermatitis (grade 2 RTOG/EORTC acute reaction) that exceeded the tolerance level. However, dermatitis was cured within a few months after BNCT. Patient 1 showed metastasis to subcutaneous tissue of the neck 19 months after BNCT. Patient 1 had brain involvement 12 months after BNCT. At present, all the patients are living, surviving 10 to 20 months after BNCT.[Conclusion]This study shows that BNCT is a quite effective therapy for the epithelial carcinomas of the head and neck. Based on the promising results and the sample size, further research is warranted on this method.

[背景]基于BNCT治疗腮腺粘液表皮样癌的成功报道，我们从2003年10月开始进行BNCT治疗复发或局部晚期头颈部上皮癌的临床试验。[患者与方法] 2003年10月至2007年9月，在KUR或JRR-4对3例患者进行了BNCT治疗。肿瘤的组织学类型、原发部位及TNM分期分别为：患者1：腺泡细胞癌;腭突腺; T4 N 0 M0，患者2：ACC ;泪囊; T4 N 0 M0，患者3：ACC ;上颌窦; T4 N 0 M0.肿瘤/正常组织硼浓度比值用18F-BPA-PEP研究得到的T/N比值（T/N比值），分别用于中子辐照前的剂量估算和BNCT后的剂量估算。在以500 mg/kg体重的剂量静脉内给予BPA的果糖溶液后，使用超热束以5.0 MW（KUR）或3.5 MW（JRR-4）的反应堆功率进行中子照射。肿瘤最深处剂量和正常皮肤和粘膜的剂量分别计划大于20 Gy Eq和小于15 Gy Eq。[结果]所有患者均获得局部完全缓解（CR）。所有患者均发生皮炎（2级RTOG/EORTC急性反应），超过耐受水平。然而，皮炎在BNCT后几个月内治愈。患者1在BNCT后19个月出现颈部皮下组织转移。患者1在BNCT后12个月出现脑受累。目前，所有患者均存活，BNCT后存活10至20个月。[结论] BNCT是治疗头颈部上皮性癌的有效方法。基于有希望的结果和样本量，进一步的研究是必要的。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Boron neutron capture therapy of advanced head and neck non-squamous cell carcinoma.

硼中子俘获治疗晚期头颈非鳞状细胞癌。

DOI：
发表时间：
2007
期刊：
影响因子：
0
作者：
粟飯原輝人;他;Aihara Teruhito et. al.;Aihara Teruhito et. al.;Aihara teruhito 他;Aihara teruhito 他;粟飯原輝人他;粟飯原輝人;Teruhito Aihara;粟飯原輝人;粟飯原輝人;粟飯原輝人;粟飯原輝人;Aihara Teruhito et. al.
通讯作者：
Aihara Teruhito et. al.

頭頚部癌に対する瑚素中性子捕捉療法

戈佐中子捕获疗法治疗头颈癌

DOI：
发表时间：
2008
期刊：
京都大学原子炉実験所第42回学術講演会報文集
影响因子：
0
作者：
粟飯原輝人;他
通讯作者：
他

Boron neutron capture therapy of advanced head and neck non-squamous cell carcinoma

硼中子俘获治疗晚期头颈部非鳞状细胞癌

DOI：
发表时间：
2007
期刊：
影响因子：
0
作者：
粟飯原輝人;他;Aihara Teruhito et. al.;Aihara Teruhito et. al.;Aihara teruhito 他;Aihara teruhito 他;粟飯原輝人他;粟飯原輝人;Teruhito Aihara
通讯作者：
Teruhito Aihara

First clinical case of boron neutron capture therapy for head and neck malignancies using 18F-BPA pet