黑色素瘤是一种转移性极高的皮肤恶性肿瘤，但传统疗法治疗效果欠佳。硼中子俘获疗法（BNCT）在黑色素瘤治疗上具有手术、化疗及常规放疗等疗法不具备的选择性杀伤肿瘤细胞的优势，但高效含硼治疗剂的缺乏严重限制了该疗法的临床发展。本课题在前期氮化硼纳米递药系统的研究基础上，拟将装载石墨烯量子点的氮化硼纳米球作为内核，琥珀酰化细胞核靶向肽修饰的骨髓间充质干细胞膜作为外壳，构建肿瘤逐级精准靶向氮化硼纳米球新型BNCT治疗/成像剂。该纳米体系通过干细胞膜表面特异性分子介导肿瘤靶向，随后响应肿瘤细胞内涵体酸性环境靶向细胞核，同时结合石墨烯量子点的荧光成像作用和氮化硼纳米球作为硼载体的特殊性能，旨在实现黑色素瘤的诊疗一体化。本项目的研究结果将为开发高效低毒的新型BNCT治疗剂提供实验和理论依据，同时为黑色素瘤的治疗提供有效的手段。

Melanoma is a highly metastatic skin cancer against which the traditional treatment is not effective. In comparison, boron neutron capture therapy (BNCT) has the advantage of selective killing tumor cells in the treatment of melanoma, which is not available in surgery, chemotherapy and conventional radiotherapy. However, the lack of effective boron-containing therapeutic agents has seriously limited the clinical development of BNCT. Based on the previous study of boron nitride nanomaterials based drug delivery system, the proposed work aims to develop a noval stem cell membrane functionalized tumor targeting boron nitride nanospheres based BNCT therapeutic/imaging agent. In this core-shell structured nanosystem, the graphene quantum dots (GQD) loaded boron nitride nanoaspheres served as the kernel, the succinylated nucleus targeting peptide modified bone marrow mesenchymal stem cell membrane as the shell. The nanosystem would target tumor by the mediation of the specific molecules on the stem cell membrane, and then target the nucleus in response to the acidic environment in the tumor cells. By combining the luminescence of GQD and the property of boron nitride as boron carrier, the nanosystem was likely to achieve the integration of melanoma diagnosis and treatment. This work could provide experimental and theoretical basis for the development of effective and biocompatible noval BNCT therapeutic agents, as well as an effective means for the clinical treatment of melanoma.