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Investigation of the retinal function and pathogenesis in diabetic retinopathy

糖尿病视网膜病变的视网膜功能及发病机制研究

基本信息

批准号：
18591904
负责人：
YOSHIDA Akitoshi
金额：
$ 2.49万
依托单位：
Asahikawa Medical College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591904/
关键词：
diabetic retinopathy retinal blood flow laser Doppler velocity endothelial function statin resveratrol C-reactive protein nitric oxide 糖尿病医療・福祉網膜血流プロレニン血管内皮 NO

项目摘要

1. Human research・The retinal blood flow may decrease in the early phase but increase in the late phase after the onset of diabetes mellitus (in submission).・The increased RBF may predict development of diabetic retinopathy in patients with type 2 diabetes (in submission).・The plasma level of NO increases in patients with type 2 diabetic patients. (Japanese J Ophthalmol, 2006)・Blockade of angiotensin type II receptor did not change retinal blood flow in healthy subjects (in submission).・Vascular endothelial dysfunction may be involved in the pathogenesis of interferon-induced retinopathy in patients with chronic hepatitis C. (Invest Ophthalmol Vis Sci, 2007)・2. In vivo animal study・Nitric oxide contributes to RBF recovery after hyperoxia, probably through the action of endothelial NOS via the ETB receptor in the vascular endothelium of the retinal arterioles, suggesting that the RBF response to hyperoxia may be used to evaluate the endothelial function of the retinal arterioles. (in su … More bmission).・Acute hyperglycemia significantly reduced the endothelial-dependent BK-induced increase in vessel diameter, bleed velocity and retinal blood flow, suggesting that hyperglycemia per se may induce the acute endothelial dysfunction of retinal arteries. (in submission).・3. in vitro animal study・Simvastatin elicits mainly an endothelium-dependent, NO-mediated dilation of retinal arterioles via activation of guanylyl cyclase (Invest Ophthalmol Vis Sci, 2007)・Resveratrol elicits endothelium-dependent and-independent dilation of retinal arterioles. Endothelium-dependent dilation is mediated by the released NO, probably via NO synthase (NOS) activation by the ERK pathway and the subsequent activation of soluble guanylyl cyclase. (Invest Ophthalmol Vis Sci, 2007)・CRP inhibits endothelium-dependent NO-mediated dilation in retinal arterioles by producing superoxide from NAD(P)H oxidase, which appears to be linked with p38 kinase and RhoA/Rho-kinase activation. (Invest Ophthalmol Vis Sci, 2008) Less

1. ·糖尿病发病后，视网膜血流量可能在早期减少，但在晚期增加（提交中）。增加的RBF可以预测2型糖尿病患者糖尿病视网膜病变的发展（提交中）。·2型糖尿病患者血浆NO水平升高。（Japanese J Ophthalmol, 2006）·阻断血管紧张素II型受体不会改变健康受试者的视网膜血流量（提交中）。·血管内皮功能障碍可能参与干扰素诱导慢性丙型肝炎患者视网膜病变的发病机制（Invest Ophthalmol Vis Sci, 2007）。·一氧化氮有助于高氧后RBF的恢复，可能是通过内皮NOS通过视网膜小动脉血管内皮中的ETB受体起作用，提示RBF对高氧的反应可用于评估视网膜小动脉的内皮功能。（在su…更多的佣金）。·急性高血糖显著降低内皮依赖性bk诱导的血管直径、出血速度和视网膜血流量的增加，提示高血糖本身可能诱导视网膜动脉急性内皮功能障碍。（在服从中）。·辛伐他汀主要通过激活胍基环化酶诱导内皮依赖性、一氧化氮介导的视网膜小动脉扩张（Invest Ophthalmol Vis Sci, 2007）·白藜芦醇诱导内皮依赖性和非依赖性视网膜小动脉扩张。内皮依赖性扩张是由释放的NO介导的，可能是通过ERK途径激活NO合成酶（NOS）和随后激活可溶性胍基环化酶。（Invest Ophthalmol Vis Sci, 2007）·CRP通过从NAD(P)H氧化酶产生超氧化物抑制内皮依赖性no介导的视网膜小动脉扩张，这似乎与p38激酶和RhoA/ rho激酶激活有关。(Invest Ophthalmol Vis Sci, 2008