Development of diagnostic tools and treatment based on the specific immune responses of VKH disease

为了建立可靠的VKH病实验室诊断方法，我们研究了VKH病特异性T细胞受体(TCR)。VKH的抗原是针对VKH的TCR池而提出来的，从VKH中很难获得针对TCR的抗体，也很难建立针对VKH的抗原的人调节性树突状细胞。眼内组织中存在多种摄取多肽抗原的细胞。将这些细胞分为3~4个细胞群，这些细胞群具有不同的细胞表面标记，可能发挥不同的功能。在脉络膜组织中，这些细胞可能作为APC刺激T细胞，而在视网膜中，这些细胞可能作为APC调节T细胞。

To develop the reliable laboratory examination for diagnosis of VKH disease, we studied the T cell receptors (TCRs) specific for VKH disease. The antigens were raised against the TCR pools specific for VKH.It was difficult to get the antibodies specific against TCRs from VKHdisease.It was also difficult to establish human regulatory dendritic cell specific to antigens for VKH disease.We studied the potential antigen presenting cells in intraocular tissues. There were several kind of cells that can uptake peptide antigens in intraocular tissues. These cells were divided into 3 to 4 groups.These cell groups had different cell surface markers and may play different functions. In the choroidal tissues, these cells may function as APCs stimulating the T cells, while in the retina, these cells may function as APCs regulating the T cells/