Reevaluation for long-term use of Extracorporeal Membrane Oxygenator

在本研究中，我们应该改进离心血泵用于长期ECMO泵，并明确了长期使用ECMO系统的问题。我们的ECMO系统由一个微型血泵和一个独特的带圆柱形血流的膜氧合器组成。我们的泵有问题，在轴承的上下部分产生血栓。第一年，我们通过慢性动物实验检查了泵的血液相容性，并通过计算流体动力学分析评估了氧合器中的血流模式。我们的血泵在下部无血栓形成，但在上部没有改善。通过CID分析，我们的氧合器在机壳角落堵塞的情况下比商用氧合器有优势。去年，我们制造了三种型号的泵，围绕上轴承进行了修改。经慢性动物实验，各型号泵的血液相容性均有改善。其中，长进气口直接引导血液流向上轴承的泵的相容性最好。通过对氧合器的研究，比较了膜空间相似的圆柱形氧合器和方柱氧合器。在气体交换性能方面，圆柱形氧合器比柱状氧合器好10%。我们的供儿童使用的氧合器，达到了AAMI对成人氧合器的标准。通过对幼犬的急性动物检查，并与我们的儿童氧合器和市售的成人氧合器进行比较，证实了这一结果。在未来，我们应该完善我们的ECMO系统，以最少的填充量和高质量的血液相容性，并进一步研究长期使用ECMO系统对器官的影响。

In this study, we should improve our centrifugal blood pump for long-term ECMO pump, and clarified the problem in prolonged use of ECMO system. Our ECMO system consisted of a miniature blood pump and a unique membrane oxygenator with cylindrical blood stream. Our pump had problem that was produced thrombus at the upper and lower parts of its bearing.Initial year, we examined blood compatibility of the pump with chronic animal examination, and assess blood flow patterns in the oxygenator by Computational Fluid Dynamics analysis. Our Blood pump was bred no thrombus formation at lower bearing, however, not improved at upper part. Our oxygenator had an advantage over commercial oxygenators in congestion at corners of casing by CID analysis.Final year, we manufactured 3-type models of pump, modifying around upper bearing. By chronic animal exam, all types of pump were improved the blood compatibility. Moreover, the pump with long inlet port for guiding blood flow directly to upper bearing was the best compatibility among them. By investigation of the oxygenator, we compared with cylindrical and square pillar oxygenators, which had similar membrane space. In gas exchange performance, cylindrical oxygenators were better 10% than pillar oxygenators. And, our oxygenator, which was for children, met AAMI standard for of oxygenator for adults. This result was confirmed by acute animal examination with puppy, under comparing with our oxygenator for child and a commercial oxygenator for adult.In the future, we should complete our ECMO system, which had minimum quantity of filling and high quality of blood compatibility, and investigate further problems against organs in long-term use of ECMO system.